{"title":"通过敏化光解引发红光/近红外线光释放","authors":"","doi":"10.1016/j.ccr.2024.216117","DOIUrl":null,"url":null,"abstract":"<div><p>Photoremovable protecting groups (PPGs) have become significant optical molecular tools in modern biomedicine. The unique property of photorelease allows noninvasively manipulating physiological processes with high spatial-temporal resolution. Red/near-infrared (NIR) light activatable is crucial for biomedical applications. Apart from red/NIR light absorbing PPGs, the short-wavelength light absorbing PPGs could also achieve photolysis upon red/NIR light excitation by simply introducing appropriate photosensitizers, displaying significant superiorities in chemical synthesis and photobleaching resistance. Besides, the main molecular scaffolds of PPGs are remained unchanged, avoiding unpredictable photolysis performance degradation. In this review, the mechanisms, design principles and biomedical applications of the sensitized photolysis will be well discussed and summarized, hoping to provide guidelines and references for developing relevant photorelease systems and their biomedical applications.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Red/near-infrared light triggered photorelease via sensitized photolysis\",\"authors\":\"\",\"doi\":\"10.1016/j.ccr.2024.216117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Photoremovable protecting groups (PPGs) have become significant optical molecular tools in modern biomedicine. The unique property of photorelease allows noninvasively manipulating physiological processes with high spatial-temporal resolution. Red/near-infrared (NIR) light activatable is crucial for biomedical applications. Apart from red/NIR light absorbing PPGs, the short-wavelength light absorbing PPGs could also achieve photolysis upon red/NIR light excitation by simply introducing appropriate photosensitizers, displaying significant superiorities in chemical synthesis and photobleaching resistance. Besides, the main molecular scaffolds of PPGs are remained unchanged, avoiding unpredictable photolysis performance degradation. In this review, the mechanisms, design principles and biomedical applications of the sensitized photolysis will be well discussed and summarized, hoping to provide guidelines and references for developing relevant photorelease systems and their biomedical applications.</p></div>\",\"PeriodicalId\":289,\"journal\":{\"name\":\"Coordination Chemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":20.3000,\"publicationDate\":\"2024-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coordination Chemistry Reviews\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010854524004636\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524004636","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Red/near-infrared light triggered photorelease via sensitized photolysis
Photoremovable protecting groups (PPGs) have become significant optical molecular tools in modern biomedicine. The unique property of photorelease allows noninvasively manipulating physiological processes with high spatial-temporal resolution. Red/near-infrared (NIR) light activatable is crucial for biomedical applications. Apart from red/NIR light absorbing PPGs, the short-wavelength light absorbing PPGs could also achieve photolysis upon red/NIR light excitation by simply introducing appropriate photosensitizers, displaying significant superiorities in chemical synthesis and photobleaching resistance. Besides, the main molecular scaffolds of PPGs are remained unchanged, avoiding unpredictable photolysis performance degradation. In this review, the mechanisms, design principles and biomedical applications of the sensitized photolysis will be well discussed and summarized, hoping to provide guidelines and references for developing relevant photorelease systems and their biomedical applications.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.