一名 EBV 阴性患者的伯基特淋巴瘤在完全缓解 20 年后极晚期复发

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2024-01-01 DOI:10.1016/j.lrr.2024.100470
Kmar Mrad , Nader Slama , Nouha Ben Abdeljalil , Zaineb Mlayah , Wiem Boufrikha , Abdelfattah Zakhama , Sarra Boukhris , Mohamed Adnene Laatiri
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引用次数: 0

摘要

伯基特淋巴瘤(BL)是一种侵袭性 B 细胞淋巴瘤,好发于儿童和成人。我们报告了一例 32 岁男性患者的病例,他来自布基特淋巴瘤非流行区,20 年前曾成功治疗过腹部布基特淋巴瘤。他自述有两个月的颈部肿胀史和一周的呼吸困难史。体格检查除左侧颌下肿块延伸至锁骨外无其他异常。颈部超声波检查发现颈部淋巴结病变。患者接受了淋巴结活检和免疫组化分析,最后确诊为 BL。最近的爱泼斯坦-巴氏病毒(EBV)感染筛查结果为阴性。我们认为这是原发疾病的极晚期复发(VLR),并按照相同的初始方案对患者进行了治疗。我们报告了一例不寻常的病例:EBV 阴性患者在首次化疗后获得完全缓解 20 年后,又出现了非流行性 BL 的 VLR。
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Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission

Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse.

We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal BL 20 years ago. He described a two-month history of cervical swelling and a one-week history of dyspnea. Physical examination was unremarkable except for a left submandibular mass that extended to the collarbone. An ultrasound of the neck revealed cervical lymphadenopathy. The patient was submitted to a lymph node biopsy with an immunohistochemical analysis, which concluded to the diagnosis of BL. Screening for recent Epstein-Barr-Virus (EBV) infection was negative. We considered this a very late relapse (VLR) of the original disease, and the patient was treated according to the same initial protocol. Unfortunately, he suffered a second relapse and died.

We report an unusual case of a VLR of nonendemic BL in an EBV-negative patient, occurring 20 years after achieving complete remission following the initial chemotherapy.

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来源期刊
Leukemia Research Reports
Leukemia Research Reports Medicine-Oncology
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
23 weeks
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