Svetlana V. Kurmaz, Ivan V. Ulyanov, Nina S. Emelyanova, Vladimir A. Kurmaz, Alexey V. Kozlov, Lev R. Sizov, Alexander Yu. Rybkin
{"title":"用于光动力疗法和荧光诊断的纳米级酞菁铝系统以及 N-乙烯基吡咯烷酮与单甲基和二甲基丙烯酸酯的两性共聚物","authors":"Svetlana V. Kurmaz, Ivan V. Ulyanov, Nina S. Emelyanova, Vladimir A. Kurmaz, Alexey V. Kozlov, Lev R. Sizov, Alexander Yu. Rybkin","doi":"10.1016/j.mencom.2024.06.007","DOIUrl":null,"url":null,"abstract":"<div><p>Water-soluble nanosized systems of aluminum phthalo- cyanine, which is a promising photosensitizer for photodynamic therapy and fluorescence diagnostics, were obtained by encapsulating it in biocompatible copolymers of <em>N</em>-vinylpyrrolidone with mono- and dimethacrylates. The physicochemical (water solubility, stability and size of nanoparticles) and photophysical (absorption and fluorescence) properties of the resulting nanoparticles in aqueous solution were determined. Quantum chemical modeling revealed the formation of coordination bonds between the Al atom of the dye and the oxygen atoms of all monomer units.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":"34 4","pages":"Pages 492-495"},"PeriodicalIF":1.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics\",\"authors\":\"Svetlana V. Kurmaz, Ivan V. Ulyanov, Nina S. Emelyanova, Vladimir A. Kurmaz, Alexey V. Kozlov, Lev R. Sizov, Alexander Yu. Rybkin\",\"doi\":\"10.1016/j.mencom.2024.06.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Water-soluble nanosized systems of aluminum phthalo- cyanine, which is a promising photosensitizer for photodynamic therapy and fluorescence diagnostics, were obtained by encapsulating it in biocompatible copolymers of <em>N</em>-vinylpyrrolidone with mono- and dimethacrylates. The physicochemical (water solubility, stability and size of nanoparticles) and photophysical (absorption and fluorescence) properties of the resulting nanoparticles in aqueous solution were determined. Quantum chemical modeling revealed the formation of coordination bonds between the Al atom of the dye and the oxygen atoms of all monomer units.</p></div>\",\"PeriodicalId\":18542,\"journal\":{\"name\":\"Mendeleev Communications\",\"volume\":\"34 4\",\"pages\":\"Pages 492-495\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mendeleev Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0959943624001846\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mendeleev Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959943624001846","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics
Water-soluble nanosized systems of aluminum phthalo- cyanine, which is a promising photosensitizer for photodynamic therapy and fluorescence diagnostics, were obtained by encapsulating it in biocompatible copolymers of N-vinylpyrrolidone with mono- and dimethacrylates. The physicochemical (water solubility, stability and size of nanoparticles) and photophysical (absorption and fluorescence) properties of the resulting nanoparticles in aqueous solution were determined. Quantum chemical modeling revealed the formation of coordination bonds between the Al atom of the dye and the oxygen atoms of all monomer units.
期刊介绍：
Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications.
Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.
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