{"title":"近红外响应式 CO/H2S 双气体纳米发电机的 \"一石三鸟 \"策略,用于高效治疗骨质疏松症","authors":"","doi":"10.1016/j.mtbio.2024.101179","DOIUrl":null,"url":null,"abstract":"<div><p>Osteoporosis (OP), the most prevalent bone degenerative disease, has become a significant public health challenge globally. Current therapies primarily target inhibiting osteoclast activity or stimulating osteoblast activation, but their effectiveness remains suboptimal. This paper introduced a “three birds, one stone” therapeutic approach for osteoporosis, employing upconversion nanoparticles (UCNPs) to create a dual-gas storage nanoplatform (UZPA-CP) targeting bone tissues, capable of concurrently generating carbon monoxide (CO) and hydrogen sulfide (H<sub>2</sub>S). Through the precise modulation of 808 nm near-infrared (NIR) light, the platform could effectively control the release of CO and H<sub>2</sub>S in the OP microenvironment, and realize the effective combination of promoting osteogenesis, inhibiting osteoclast activity, and improving the immune microenvironment to achieve the therapeutic effect of OP. High-throughput sequencing results further confirmed the remarkable effectiveness of the nanoplatform in inhibiting apoptosis, modulating inflammatory response, inhibiting osteoclast differentiation and regulating multiple immune signaling pathways. The gas storage nanoplatform not only optimized the OP microenvironment with the assistance of NIR, but also restored the balance between osteoblasts and osteoclasts. 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Current therapies primarily target inhibiting osteoclast activity or stimulating osteoblast activation, but their effectiveness remains suboptimal. This paper introduced a “three birds, one stone” therapeutic approach for osteoporosis, employing upconversion nanoparticles (UCNPs) to create a dual-gas storage nanoplatform (UZPA-CP) targeting bone tissues, capable of concurrently generating carbon monoxide (CO) and hydrogen sulfide (H<sub>2</sub>S). Through the precise modulation of 808 nm near-infrared (NIR) light, the platform could effectively control the release of CO and H<sub>2</sub>S in the OP microenvironment, and realize the effective combination of promoting osteogenesis, inhibiting osteoclast activity, and improving the immune microenvironment to achieve the therapeutic effect of OP. High-throughput sequencing results further confirmed the remarkable effectiveness of the nanoplatform in inhibiting apoptosis, modulating inflammatory response, inhibiting osteoclast differentiation and regulating multiple immune signaling pathways. The gas storage nanoplatform not only optimized the OP microenvironment with the assistance of NIR, but also restored the balance between osteoblasts and osteoclasts. 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引用次数: 0
摘要
骨质疏松症(OP)是最普遍的骨退行性疾病,已成为全球公共卫生面临的重大挑战。目前的疗法主要以抑制破骨细胞活性或刺激成骨细胞活化为目标,但效果仍不理想。本文介绍了一种 "一石三鸟 "的骨质疏松症治疗方法,即利用上转换纳米粒子(UCNPs)创建一种针对骨组织的双气体存储纳米平台(UZPA-CP),能够同时产生一氧化碳(CO)和硫化氢(H2S)。通过对808 nm近红外光的精确调控,该平台可有效控制OP微环境中CO和H2S的释放,实现促进成骨、抑制破骨细胞活性和改善免疫微环境的有效结合,达到OP的治疗效果。高通量测序结果进一步证实了该纳米平台在抑制细胞凋亡、调节炎症反应、抑制破骨细胞分化和调控多种免疫信号通路方面的显著效果。储气纳米平台不仅在近红外的帮助下优化了 OP 的微环境,还恢复了成骨细胞和破骨细胞之间的平衡。这种以改善骨微环境、促进成骨和抑制破骨细胞活性为重点的综合治疗策略为治疗代谢性骨病提供了一种理想的新方案。
“Three birds, one stone” strategy of NIR-responsive CO/H2S dual-gas Nanogenerator for efficient treatment of osteoporosis
Osteoporosis (OP), the most prevalent bone degenerative disease, has become a significant public health challenge globally. Current therapies primarily target inhibiting osteoclast activity or stimulating osteoblast activation, but their effectiveness remains suboptimal. This paper introduced a “three birds, one stone” therapeutic approach for osteoporosis, employing upconversion nanoparticles (UCNPs) to create a dual-gas storage nanoplatform (UZPA-CP) targeting bone tissues, capable of concurrently generating carbon monoxide (CO) and hydrogen sulfide (H2S). Through the precise modulation of 808 nm near-infrared (NIR) light, the platform could effectively control the release of CO and H2S in the OP microenvironment, and realize the effective combination of promoting osteogenesis, inhibiting osteoclast activity, and improving the immune microenvironment to achieve the therapeutic effect of OP. High-throughput sequencing results further confirmed the remarkable effectiveness of the nanoplatform in inhibiting apoptosis, modulating inflammatory response, inhibiting osteoclast differentiation and regulating multiple immune signaling pathways. The gas storage nanoplatform not only optimized the OP microenvironment with the assistance of NIR, but also restored the balance between osteoblasts and osteoclasts. This comprehensive therapeutic strategy focused on improving the bone microenvironment, promoting osteogenesis and inhibiting osteoclast activity provides an ideal new solution for the treatment of metabolic bone diseases.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).