{"title":"7S,8R-二羟基去氧石杉碱甲：一种来自八目鳗马钱子的天然二氢呋喃类生物碱","authors":"Jyh-Horng Sheu , Li-Guo Zheng , You-Ying Chen , Su-Ying Chien , Ping-Jyun Sung","doi":"10.1016/j.phytol.2024.07.012","DOIUrl":null,"url":null,"abstract":"<div><p>Chemical screening of the octocoral <em>Sarcophyton stellatum</em> led to the isolation of a natural dihydrofuranocembranoid, 7<em>S</em>,8<em>R</em>-dihydroxydeepoxysarcophytoxide (<strong>1</strong>). Single-crystal X-ray diffraction analysis was conducted to determine the absolute configuration of <strong>1</strong>, and its structure was confirm using two-dimensional NMR experiments and a literature review. Dihydrofuranocembranoid <strong>1</strong> actively enhanced alkaline phosphatase activity.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 14-17"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"7S,8R-Dihydroxydeepoxysarcophytoxide: A natural dihydrofuranocembranoid from the octocoral Sarcophyton stellatum\",\"authors\":\"Jyh-Horng Sheu , Li-Guo Zheng , You-Ying Chen , Su-Ying Chien , Ping-Jyun Sung\",\"doi\":\"10.1016/j.phytol.2024.07.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chemical screening of the octocoral <em>Sarcophyton stellatum</em> led to the isolation of a natural dihydrofuranocembranoid, 7<em>S</em>,8<em>R</em>-dihydroxydeepoxysarcophytoxide (<strong>1</strong>). Single-crystal X-ray diffraction analysis was conducted to determine the absolute configuration of <strong>1</strong>, and its structure was confirm using two-dimensional NMR experiments and a literature review. Dihydrofuranocembranoid <strong>1</strong> actively enhanced alkaline phosphatase activity.</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"63 \",\"pages\":\"Pages 14-17\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024001095\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001095","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
通过对八目鳗马钱子的化学筛选，分离出了一种天然的二氢呋喃类植物激素--7S,8R-二羟基去氧马钱子碱（1）。通过单晶 X 射线衍射分析确定了 1 的绝对构型，并利用二维核磁共振实验和文献综述确认了其结构。二氢呋喃类保护植物 1 能有效增强碱性磷酸酶的活性。
7S,8R-Dihydroxydeepoxysarcophytoxide: A natural dihydrofuranocembranoid from the octocoral Sarcophyton stellatum
Chemical screening of the octocoral Sarcophyton stellatum led to the isolation of a natural dihydrofuranocembranoid, 7S,8R-dihydroxydeepoxysarcophytoxide (1). Single-crystal X-ray diffraction analysis was conducted to determine the absolute configuration of 1, and its structure was confirm using two-dimensional NMR experiments and a literature review. Dihydrofuranocembranoid 1 actively enhanced alkaline phosphatase activity.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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