{"title":"沟通型 DeBakey IIIb 慢性主动脉夹层动脉瘤初次手术修复的长期疗效","authors":"Shuhei Miura MD, Yutaka Iba MD, PhD, Kei Mukawa MD, Keitaro Nakanishi MD, Takakimi Mizuno MD, Ayaka Arihara MD, Tsuyoshi Shibata MD, PhD, Junji Nakazawa MD, PhD, Tomohiro Nakajima MD, PhD, Nobuyoshi Kawaharada MD, PhD","doi":"10.1016/j.xjon.2024.05.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate the long-term outcomes of surgical strategies for communicating DeBakey IIIb chronic dissecting aortic aneurysm, considering the optimal primary surgical repair to prevent aortic events.</p></div><div><h3>Methods</h3><p>From 2002 to 2021, 101 patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm who underwent surgical repair were categorized based on the primary surgical repair: 1-stage repair of thoracoabdominal aortic aneurysm (TAAAR) (n = 22) or staged repair, such as descending thoracic aneurysm repair (DTAR) (n = 43) or total arch replacement with elephant trunk implantation (TARET) (n = 25), and thoracic endovascular aortic repair (TEVAR) (n = 11). Early and late postoperative outcomes were compared among the groups.</p></div><div><h3>Results</h3><p>Early outcomes for TAAAR, DTAR, TARET, and TEVAR were associated with the incidence of stroke (9.1% vs 0% vs 4.0% vs 9.1%, respectively), spinal cord injury (13.6% vs 4.7% vs 8.0% vs 0%, respectively), and in-hospital mortality (9.1% vs 2.3% vs 0% vs 9.1%, respectively). During follow-up, the 10-year overall survival and 7-year aortic event-free rates for TAAAR, DTAR, TARET, and TEVAR were 61.8%, 71.6%, 21.5%, and 26.5% and 93.8%, 84.3%, 74.4%, and 51.4%, respectively. TAAAR had significantly higher overall survival (<em>P</em> = .05) and aortic event-free rates (<em>P</em> = .03) than TEVAR. TARET (hazard ratio, 2.27; <em>P</em> < .01) and TEVAR (hazard ratio, 3.40; <em>P</em> < .01) were independently associated with the incidence of aortic events during follow-up.</p></div><div><h3>Conclusions</h3><p>Considering the optimal primary surgical repair based on long-term outcomes, TEVAR was not a durable treatment option. Patient-specific TAAAR or DTAR should be considered rather than defaulting to minimally invasive primary repairs for all patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm.</p></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"20 ","pages":"Pages 1-13"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666273624001293/pdfft?md5=12a1cfd48f6c60ac1e3e2435c9c36f1e&pid=1-s2.0-S2666273624001293-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Long-term outcomes of primary surgical repair for communicating DeBakey IIIb chronic dissecting aortic aneurysm\",\"authors\":\"Shuhei Miura MD, Yutaka Iba MD, PhD, Kei Mukawa MD, Keitaro Nakanishi MD, Takakimi Mizuno MD, Ayaka Arihara MD, Tsuyoshi Shibata MD, PhD, Junji Nakazawa MD, PhD, Tomohiro Nakajima MD, PhD, Nobuyoshi Kawaharada MD, PhD\",\"doi\":\"10.1016/j.xjon.2024.05.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study aimed to evaluate the long-term outcomes of surgical strategies for communicating DeBakey IIIb chronic dissecting aortic aneurysm, considering the optimal primary surgical repair to prevent aortic events.</p></div><div><h3>Methods</h3><p>From 2002 to 2021, 101 patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm who underwent surgical repair were categorized based on the primary surgical repair: 1-stage repair of thoracoabdominal aortic aneurysm (TAAAR) (n = 22) or staged repair, such as descending thoracic aneurysm repair (DTAR) (n = 43) or total arch replacement with elephant trunk implantation (TARET) (n = 25), and thoracic endovascular aortic repair (TEVAR) (n = 11). Early and late postoperative outcomes were compared among the groups.</p></div><div><h3>Results</h3><p>Early outcomes for TAAAR, DTAR, TARET, and TEVAR were associated with the incidence of stroke (9.1% vs 0% vs 4.0% vs 9.1%, respectively), spinal cord injury (13.6% vs 4.7% vs 8.0% vs 0%, respectively), and in-hospital mortality (9.1% vs 2.3% vs 0% vs 9.1%, respectively). During follow-up, the 10-year overall survival and 7-year aortic event-free rates for TAAAR, DTAR, TARET, and TEVAR were 61.8%, 71.6%, 21.5%, and 26.5% and 93.8%, 84.3%, 74.4%, and 51.4%, respectively. TAAAR had significantly higher overall survival (<em>P</em> = .05) and aortic event-free rates (<em>P</em> = .03) than TEVAR. TARET (hazard ratio, 2.27; <em>P</em> < .01) and TEVAR (hazard ratio, 3.40; <em>P</em> < .01) were independently associated with the incidence of aortic events during follow-up.</p></div><div><h3>Conclusions</h3><p>Considering the optimal primary surgical repair based on long-term outcomes, TEVAR was not a durable treatment option. Patient-specific TAAAR or DTAR should be considered rather than defaulting to minimally invasive primary repairs for all patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm.</p></div>\",\"PeriodicalId\":74032,\"journal\":{\"name\":\"JTCVS open\",\"volume\":\"20 \",\"pages\":\"Pages 1-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666273624001293/pdfft?md5=12a1cfd48f6c60ac1e3e2435c9c36f1e&pid=1-s2.0-S2666273624001293-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JTCVS open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666273624001293\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JTCVS open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666273624001293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在评估沟通型DeBakey IIIb慢性剥离性主动脉瘤手术策略的长期疗效,同时考虑到预防主动脉事件的最佳主要手术修复方法。方法从2002年到2021年,101例沟通型DeBakey IIIb慢性剥离性主动脉瘤患者接受了手术修复,根据主要手术修复方法进行分类:一期胸腹主动脉瘤修补术(TAAAR)(22 例)或分期修补术,如降胸动脉瘤修补术(DTAR)(43 例)或象鼻干植入全弓置换术(TARET)(25 例),以及胸腔内血管主动脉修补术(TEVAR)(11 例)。结果TAAAR、DTAR、TARET和TEVAR的早期结果与中风(分别为9.1% vs 0% vs 4.0% vs 9.1%)、脊髓损伤(分别为13.6% vs 4.7% vs 8.0% vs 0%)和院内死亡率(分别为9.1% vs 2.3% vs 0% vs 9.1%)相关。在随访期间,TAAAR、DTAR、TARET和TEVAR的10年总生存率和7年无主动脉事件发生率分别为61.8%、71.6%、21.5%和26.5%,以及93.8%、84.3%、74.4%和51.4%。TAAAR 的总生存率(P = .05)和无主动脉事件发生率(P = .03)明显高于 TEVAR。TARET(危险比,2.27;P <.01)和 TEVAR(危险比,3.40;P <.01)与随访期间主动脉事件的发生率独立相关。对于所有患有交流性DeBakey IIIb型慢性剥脱性主动脉瘤的患者,应考虑针对患者的TAAAR或DTAR,而不是默认采用微创初级修复术。
Long-term outcomes of primary surgical repair for communicating DeBakey IIIb chronic dissecting aortic aneurysm
Objective
This study aimed to evaluate the long-term outcomes of surgical strategies for communicating DeBakey IIIb chronic dissecting aortic aneurysm, considering the optimal primary surgical repair to prevent aortic events.
Methods
From 2002 to 2021, 101 patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm who underwent surgical repair were categorized based on the primary surgical repair: 1-stage repair of thoracoabdominal aortic aneurysm (TAAAR) (n = 22) or staged repair, such as descending thoracic aneurysm repair (DTAR) (n = 43) or total arch replacement with elephant trunk implantation (TARET) (n = 25), and thoracic endovascular aortic repair (TEVAR) (n = 11). Early and late postoperative outcomes were compared among the groups.
Results
Early outcomes for TAAAR, DTAR, TARET, and TEVAR were associated with the incidence of stroke (9.1% vs 0% vs 4.0% vs 9.1%, respectively), spinal cord injury (13.6% vs 4.7% vs 8.0% vs 0%, respectively), and in-hospital mortality (9.1% vs 2.3% vs 0% vs 9.1%, respectively). During follow-up, the 10-year overall survival and 7-year aortic event-free rates for TAAAR, DTAR, TARET, and TEVAR were 61.8%, 71.6%, 21.5%, and 26.5% and 93.8%, 84.3%, 74.4%, and 51.4%, respectively. TAAAR had significantly higher overall survival (P = .05) and aortic event-free rates (P = .03) than TEVAR. TARET (hazard ratio, 2.27; P < .01) and TEVAR (hazard ratio, 3.40; P < .01) were independently associated with the incidence of aortic events during follow-up.
Conclusions
Considering the optimal primary surgical repair based on long-term outcomes, TEVAR was not a durable treatment option. Patient-specific TAAAR or DTAR should be considered rather than defaulting to minimally invasive primary repairs for all patients with communicating DeBakey IIIb chronic dissecting aortic aneurysm.