北印度年轻和老年口腔鳞状细胞癌患者临床病理特征的比较

G. Sharma, M. Kamboj, A. Narwal, A. Devi, J. Yadav, M. Sharma
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引用次数: 0

摘要

导言口腔鳞状细胞癌(OSCC)是头颈部最常见的上皮恶性肿瘤之一。虽然它主要影响老年人,但近年来在年轻人群中的发病率也呈上升趋势,令人担忧。本研究旨在比较我院 OSCC 的临床病理特征,以区分年轻组和老年组。方法在本回顾性研究中,我们检索了经组织病理学证实的 OSCC 病例,并根据年龄将其分为两组。对人口统计学数据和组织病理学参数进行评估。收集到的数据通过描述性分析、卡方检验、卡帕检验和多项式逻辑回归检验进行统计分析。结果 在 707 名 OSCC 患者中,585 人年龄超过 40 岁,122 人年龄在 40 岁或以下。两组患者的观察结果相似,都有高度角质化、中度核多形、3 型侵袭模式、低肿瘤出芽、高基质和低瘤内淋巴细胞浸润,但淋巴浆细胞浸润在较多年轻病例中表现明显。尽管 OSCC 在年轻人中的发病率增加令人担忧,但仍有必要在未来开展样本量更大的多中心研究,以进一步了解 OSCC 在年轻人中的表现和预后。
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Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma

Introduction

Oral squamous cell carcinoma (OSCC) ranks among the most prevalent epithelial malignancies in the head and neck region. Although it predominantly affects older individuals, there has been a concerning rise in incidence among the younger population in recent years. This study aimed to compare the clinicopathological features of OSCC at our institution distinguishing between young and older age groups.

Methods

In the present retrospective study, histopathologically confirmed cases of OSCC were retrieved and assigned into two groups based on their age. Demographic data along with histopathological parameters were assessed. The data collected were statistically analysed using descriptive analysis, chi-square, kappa and multinomial logistic regression tests. A p-value less than or equal to 0.05 was considered statistically significant.

Results

Of the 707 OSCC patients, 585 were over 40 years old, while 122 were 40 or younger. Both the groups exhibited comparable observations with a high degree of keratinization, moderate nuclear pleomorphism, type 3 pattern of invasion, low tumor budding, high stromal and low intratumoral infiltration of lymphocytes, except lymphoplasmacytic infiltrate which was marked in a higher number of young cases.

Conclusion

OSCC in young and older individuals exhibited similar clinical as well as histopathological findings. Although the increased incidence of OSCC in the young is a cause of concern, so future multicentric studies with a larger sample size are warranted, to shed more light on the behavior and prognosis of OSCC in the young.

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