Rücktitelbild: Copper-Induced Supramolecular Peptide Assemblies for Multi-Pathway Cell Death and Tumor Inhibition (Angew. Chem. 34/2024)

The immunosuppressive tumor microenvironment leads to insufficient infiltration of effector lymphocytes, significantly weakening the anti-tumor immune response and promoting the tumor to become “cold”. In the cover image, tumor cells are representend as icebergs, with organelles as ice blocks floating on the ice surface. The copper peptide nanoparticles are meteorites falling from the sky, attacking multiple organelles. The ice begins to melt, symbolizing the elicited multiple cell death pathways, and also indicating the transformation of cold tumors into hot tumors, as illustrated by Ling Wang, Jie Gao et al. in their Research Article (e202406602).