在全关节置换术中使用类金刚石碳膜的可行性:综述。

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-08-13 DOI:10.1007/s10856-024-06814-x
Anurag Roy, Annette Bennett, Lisa Pruitt
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引用次数: 0

摘要

类金刚石碳(DLC)具有良好的生物三热力学特性,已被用作各种技术应用的首选涂层材料。本文将探讨将 DLC 应用于骨科关节植入物的可能性。随着骨关节炎患者人数的不断增加,以及骨关节炎患者逐渐年轻化和活跃化,迫切需要提高传统全关节置换术(TJR)的性能和完整性。当代关节置换装置使用金属聚合物关节来恢复磨损、受损或病变软骨的功能。聚合物组件的磨损问题已通过交联和抗氧化剂得到解决;但在金属组件方面,与腐蚀和体内金属离子释放有关的并发症仍然存在。通过这篇综述文章,我们探讨了在金属轴承表面使用 DLC 涂层的问题,并阐明了为什么这项技术可能成为解决整形外科电化学难题的可行方案。通过对三材料表征方法的评估,研究了 DLC 涂层的不同特性及其在 TJR 中的可行性。还讨论了涂层-基底界面的整体表征以及此类系统的磨损性能。与所有用于 TJR 的生物材料一样,我们需要认真考虑潜在的体内挑战。我们提出了 DLC 涂层的一些注意事项,包括分层、疏水性以及文献中其他相互矛盾和过时的研究结果。我们建议审慎探索将 DLC 薄膜作为 TJR 金属组件的潜在涂层,以解决磨损、金属离子释放和腐蚀等相关问题。最后,我们建议只有在解决了本文概述的所有挑战和问题后,才能将 DLC 用于临床。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Feasibility of using diamond-like carbon films in total joint replacements: a review

Diamond-like Carbon (DLC) has been used as a coating material of choice for a variety of technological applications owing to its favorable bio-tribo-thermo-mechanical characteristics. Here, the possibility of bringing DLC into orthopedic joint implants is examined. With ever increasing number of patients suffering from osteoarthritis as well as with the ingress of the osteoarthritic joints’ malaise into younger and more active demographics, there is a pressing need to augment the performance and integrity of conventional total joint replacements (TJRs). Contemporary joint replacement devices use metal-on-polymer articulations to restore function to worn, damaged or diseased cartilage. The wear of polymeric components has been addressed using crosslinking and antioxidants; however, in the context of the metallic components, complications pertaining to corrosion and metal ion release inside the body still persist. Through this review article, we explore the use of DLC coatings on metallic bearing surfaces and elucidate why this technology might be a viable solution for ongoing electrochemical challenges in orthopedics. The different characteristics of DLC coatings and their feasibility in TJRs are examined through assessment of tribo-material characterization methods. A holistic characterization of the coating-substrate interface and the wear performance of such systems are discussed. As with all biomaterials used in TJRs, we need mindful consideration of potential in-vivo challenges. We present a few caveats for DLC coatings including delamination, hydrophobicity, and other conflicting as well as outdating findings in the literature. We recommend prudently exploring DLC films as potential coatings on metallic TJR components to solve the problems pertaining to wear, metal ion release, and corrosion. Ultimately, we advise bringing DLC into clinical use only after addressing all challenges and concerns outlined in this article.

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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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