{"title":"蠕虫的烦恼：螺旋虫给 T 细胞带来麻烦","authors":"","doi":"10.1016/j.immuni.2024.07.014","DOIUrl":null,"url":null,"abstract":"<p>Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4<sup>+</sup> T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.</p>","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"30 1","pages":""},"PeriodicalIF":25.5000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Wriggly woes: Helminths stirring up T cell trouble\",\"authors\":\"\",\"doi\":\"10.1016/j.immuni.2024.07.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4<sup>+</sup> T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.</p>\",\"PeriodicalId\":13269,\"journal\":{\"name\":\"Immunity\",\"volume\":\"30 1\",\"pages\":\"\"},\"PeriodicalIF\":25.5000,\"publicationDate\":\"2024-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.immuni.2024.07.014\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.immuni.2024.07.014","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
了解免疫反应变异的决定因素对制定治疗方案至关重要。Even 等人的研究表明，天真的 CD4+ T 细胞转录异质性会因蠕虫感染而改变，导致免疫反应受损，而不依赖于寄生虫。
Wriggly woes: Helminths stirring up T cell trouble
Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4+ T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.
期刊介绍：
Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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