对 MPOX 感染的先天免疫反应:机制与免疫逃逸

IF 4.7 3区 医学 Q2 IMMUNOLOGY Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-08-13 DOI:10.1159/000540815
Reza Parnian, Fatemeh Heydarifard, Fatemeh Sadat Mousavi, Zahra Heydarifard, Milad Zandi
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引用次数: 0

摘要

2022 年,麻腮风(原猴痘)在非流行国家再次出现,由于其传播性强、死亡率高,引起了全球健康的广泛关注。抗击 Mpox 的一大挑战是其躲避宿主先天免疫系统的能力,而先天免疫系统是抵御病毒感染的第一道防线。Mpox 编码的各种蛋白质会干扰关键的抗病毒途径和机制,如核因子卡巴 B(NF-κB)信号传导、细胞因子产生、补体和炎性体激活以及趋化因子结合。这些蛋白质会调节干扰素、白细胞介素和收费样受体等先天性免疫介质的表达和功能,并损害自然杀伤细胞等先天性免疫细胞的招募和激活。通过抑制或改变这些先天性免疫反应,Mpox 增强了其在宿主组织和器官中的复制和感染,从而导致全身炎症、组织损伤和器官衰竭。这项研究揭示了 Mpox 与宿主先天免疫之间的分子和细胞相互作用,并确定了抗病毒干预的潜在靶点和策略。
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Innate Immune Response to Monkeypox Virus Infection: Mechanisms and Immune Escape.

Background: The reemergence of monkeypox virus (Mpox, formerly monkeypox) in 2022 in non-endemic countries has raised significant concerns for global health due to its high transmissibility and mortality rate. A major challenge in combating Mpox is its ability to evade the host's innate immune system, the first line of defense against viral infections.

Summary: Mpox encodes various proteins that interfere with key antiviral pathways and mechanisms, such as the nuclear factor kappa B signaling, cytokine production, complement and inflammasome activation, and chemokine binding. These proteins modulate the expression and function of innate immune mediators, such as interferons, interleukins, and Toll-like receptors, and impair the recruitment and activation of innate immune cells, such as natural killer cells. By suppressing or altering these innate immune responses, Mpox enhances its replication and infection in the host tissues and organs, leading to systemic inflammation, tissue damage, and organ failure.

Key messages: This study reveals new insights into the molecular and cellular interactions between Mpox and the host's innate immune system. It identifies potential targets and strategies for antiviral interventions, highlighting the importance of understanding these interactions to develop effective treatments and improve global health responses to Mpox outbreaks.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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