蜂蜜和聚维酮碘对急性撕裂伤口愈合的影响:随机对照试验研究。

IF 1.5 4区 医学 Q3 DERMATOLOGY Journal of wound care Pub Date : 2024-08-02 DOI:10.12968/jowc.2022.0020
Kevin Leonard Suryadinata, Adi Basuki, Agustini Song, Nabila Viera Yovita, Adriani Purnasakti Pakan, Asian Edward Sagala
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引用次数: 0

摘要

目的:急性撕裂伤(ALW)是印度尼西亚最常见的伤害之一,可能会导致严重的发病率。在农村地区,聚维酮碘和蜂蜜是常用的伤口敷料。本研究旨在确定与石蜡纱布和常用的聚维酮碘相比,蜂蜜在改善ALW愈合时间方面的效果:本研究是一项单盲、试验性随机对照试验(RCT),分为三个干预组(蜂蜜、聚维酮碘和石蜡)。研究结果包括伤口愈合时间、缓慢愈合、二次愈合、感染迹象、伤口开裂、水肿、浸渍、坏死、渗出和费用:共纳入 35 名患者(男女比例:4:1),平均年龄为 22.5 岁(6-47 岁),根据伤口位置和伤口敷料的选择,采用预定的随机方法将其随机分配到治疗组:蜂蜜组,12 人;聚维酮碘组,11 人;石蜡组,12 人,其中一名患者失去随访机会。各组伤口均及时愈合,聚维酮碘组和石蜡组的平均愈合时间分别为 9.45±5.31 天和 11.09±5.14 天,蜂蜜组的中位愈合时间为 10(3-19)天(P>0.05)。与其他组相比,蜂蜜组有更多伤口在≤10 天内愈合。聚维酮碘组和蜂蜜组的不良反应都较少,而后者的成本最低:在这项研究中,与石蜡相比,蜂蜜在加快愈合时间方面具有临床疗效,且成本较低,与聚维酮碘相当。今后应继续进行样本量更大的 RCT 研究,以确定蜂蜜在 ALW 治疗中的作用。
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Effect of honey and povidone-iodine on acute laceration wound healing: a pilot randomised controlled trial study.

Objective: Acute laceration wound (ALW) is one of the most common injuries in Indonesia with potential significant morbidities. In rural areas, povidone-iodine and honey are commonly used as wound dressings. This study aimed to identify the effectiveness of honey compared to paraffin gauze and the commonly used povidone-iodine in improving ALW healing time.

Method: This study was a single-blind, pilot randomised controlled trial (RCT) with three intervention groups (honey, povidone-iodine, and paraffin). The outcomes were wound healing time, slow healing, secondary healing, signs of infection, wound dehiscence, oedema, maceration, necrosis, exudate and cost.

Results: A total of 35 patients (male to female ratio: 4:1), with a mean age of 22.5 (range: 6-47) years, were included and randomised to treatment groups using predetermined randomisation according to wound location and wound dressing selection: honey group, n=12; povidone-iodine group, n=11; paraffin group, n=12 with one patient lost to follow-up. All groups achieved timely healing, with a mean healing time of 9.45±5.31 days and 11.09±5.14 days for the povidone-iodine and paraffin groups, respectively, and a median healing time of 10 (3-19) days for the honey group (p>0.05). More wounds in the honey group achieved healing in ≤10 days compared with the other groups. Both povidone-iodine and honey groups had fewer adverse events, with the latter having the lowest cost.

Conclusion: In this study, honey was clinically effective in accelerating healing time with a lower cost compared to paraffin, and was comparable to povidone-iodine. Future RCTs with a larger sample size should be pursued to determine honey's role in ALW treatment.

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来源期刊
Journal of wound care
Journal of wound care DERMATOLOGY-
CiteScore
2.90
自引率
10.50%
发文量
215
期刊介绍: Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.
期刊最新文献
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