睡眠与心脏代谢风险因素和心血管疾病的关系:观察性研究和 "泯灭随机 "研究综述。

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY Sleep Medicine Reviews Pub Date : 2024-05-31 DOI:10.1016/j.smrv.2024.101965
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引用次数: 0

摘要

两位研究人员独立评估了截至 2023 年 2 月 5 日在 PubMed、Web of Science、Embase 和 Cochrane Library 上发表的研究,以调查睡眠特征与心血管代谢风险因素以及心血管疾病的关系。本研究共纳入了 14 篇系统综述(包括 23 项元分析)和 11 项孟德尔随机(MR)研究。在观察性研究中,睡眠时间短与肥胖、2 型糖尿病(T2D)、高血压、中风和冠心病(CHD)的风险较高有关,而只有孟德尔随机分析证实了睡眠时间短与肥胖、高血压和冠心病的因果关系。同样,在观察性研究中,睡眠时间长与肥胖症、T2D、高血压、中风和冠心病的风险较高有关,但磁共振分析均不支持这一点。观察性研究和磁共振研究都表明,失眠会增加高血压、中风和冠心病的风险。在观察性研究中,午睡与T2D和CHD风险升高有关,而磁共振分析证实了午睡与T2D的因果关系。此外,在观察性研究和磁共振研究中,打鼾与中风和冠心病的风险增加有关。这项研究巩固了睡眠特征与心血管代谢风险因素和心血管疾病之间因果关系的现有证据。
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Associations of sleep with cardiometabolic risk factors and cardiovascular diseases: An umbrella review of observational and mendelian randomization studies

Two researchers independently assessed studies published up to February 5, 2023, across PubMed, Web of Science, Embase, and Cochrane Library, to investigate the associations of sleep traits with cardiometabolic risk factors, as well as with cardiovascular diseases. Fourteen systematic reviews consisting of 23 meta-analyses, and 11 Mendelian randomization (MR) studies were included in this study. Short sleep duration was associated with a higher risk of obesity, type 2 diabetes (T2D), hypertension, stroke, and coronary heart disease (CHD) in observational studies, while a causal role was only demonstrated in obesity, hypertension, and CHD by MR. Similarly, long sleep duration showed connections with a higher risk of obesity, T2D, hypertension, stroke, and CHD in observational studies, none was supported by MR analysis. Both observational and MR studies indicated heightened risks of hypertension, stroke, and CHD in relation to insomnia. Napping was linked to elevated risks of T2D and CHD in observational studies, with MR analysis confirming a causal role in T2D. Additionally, snoring was correlated with increased risks of stroke and CHD in both observational and MR studies. This work consolidates existing evidence on a causal relationship between sleep characteristics and cardiometabolic risk factors, as well as cardiovascular diseases.

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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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