姜黄素对脊髓损伤的保护作用

IF 3.4 3区 医学 Q1 ORTHOPEDICS JOR Spine Pub Date : 2024-08-14 DOI:10.1002/jsp2.1364
Seyed Mehrad Razavi, Danial Khayatan, Zahra Najafi Arab, Yasamin Hosseini, Maryam Khanahmadi, Saeideh Momtaz, Tannaz Jamialahmadi, Thomas P. Johnston, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
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引用次数: 0

摘要

背景 过去几十年来,随着人口老龄化的加剧,神经系统疾病和神经退行性疾病的发病率也急剧上升。神经退行性疾病会降低患者的生活质量,并给医疗系统带来高昂的成本。这些缓慢进展的疾病会导致患者出现功能、知觉和行为障碍。因此,神经退行性损伤一直是科学家和临床医生感兴趣的课题。脊髓损伤(SCI)就是其中一种疾病。脊髓损伤可导致不可逆的损伤,主要分为两种亚型:创伤性和非创伤性,每种亚型的病理生理学特征都截然不同。 目的 本综述旨在收集姜黄素(Cur)有益作用的相关信息,特别强调其对脊髓损伤(SCI)患者的抗炎特性。 材料与amp; 方法 该综述整理了大量体内、体外和临床试验数据,这些数据记录了姜黄素对 SCI 的影响。它研究了服用 CUR 后病理生理途径的调节和炎症级联的调节。 结果 有研究表明,涉及核因子红细胞 2 相关因子 2(Nrf2)、核因子卡巴 B(NF-kB)和转化生长因子 beta(TGF-β)信号通路的各种病理生理过程会加重 SCI 造成的损伤。服用 CUR 可调节这些信号通路,从而减轻 SCI 并发症。 讨论 抗炎化合物,尤其是 CUR,可以调节这些病理生理通路并调节炎症级联。姜黄素是一种著名的天然产品,具有显著的抗炎作用,已在实验和临床试验中得到广泛证实。 结论 姜黄素改变 Nrf2、NF-kB 和 TGF-β 信号通路关键步骤的潜力表明,它可能在减轻 SCI 并发症方面发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Protective effects of curcumin against spinal cord injury

Background

In parallel with population aging, the prevalence of neurological and neurodegenerative diseases has been dramatically increasing over the past few decades. Neurodegenerative diseases reduce the quality of life of patients and impose a high cost on the health system. These slowly progressive diseases can cause functional, perceptual, and behavioral deficits in patients. Therefore, neurodegenerative impairments have always been an interesting subject for scientists and clinicians. One of these diseases is spinal cord injury (SCI). SCI can lead to irreversible damage and is classified into two main subtypes: traumatic and non-traumatic, each with very different pathophysiological features.

Aims

This review aims to gather relevant information about the beneficial effects of curcumin (Cur), with specific emphasis on its anti-inflammatory properties towards spinal cord injury (SCI) patients.

Materials & Methods

The review collates data from extensive in-vitro, in-vivo, and clinical trials documenting the effects of CUR on SCI. It examines the modulation of pathophysiological pathways and regulation of the inflammatory cascades after CUR administration.

Results

Various pathophysiological processes involving the nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-kB), and transforming growth factor beta (TGF-β) signaling pathways have been suggested to exacerbate damages resulting from SCI. CUR administration showed to modulate these signaling pathways which lead to attenuation of SCI complications.

Discussion

Anti-inflammatory compounds, particularly CUR, can modulate these pathophysiological pathways and regulate the inflammatory cascades. CUR, a well-known natural product with significant anti-inflammatory effects, has been extensively documented in experimental and clinical trials.

Conclusion

Curcumin's potential to alter key steps in the Nrf2, NF-kB, and TGF-β signaling pathways suggests that it may play a role in attenuating SCI complications.

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来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
期刊最新文献
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