疾病中皮肤细胞的共生微生物调控

IF 20.6 1区 医学 Q1 MICROBIOLOGY Cell host & microbe Pub Date : 2024-08-14 DOI:10.1016/j.chom.2024.07.020
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引用次数: 0

摘要

人体皮肤是各种共生微生物的宿主,它们构成了一个庞大的微生物群落。这些微生物居民和宿主细胞之间的相互交流维持着皮肤层的形态和功能属性,对微环境和组织的平衡做出了不可或缺的贡献。因此,皮肤屏障的破坏或微生物群落的失衡会对宿主细胞的行为产生深远影响。这种影响由微生物本身或其代谢产物介导,表现为多种结果。在这篇综述中,我们研究了现有的知识,以深入了解微生物群在健康和疾病状态下对皮肤细胞表现出的微妙行为。这些相互作用为未来基于微生物群的疗法预防和治疗皮肤病提供了潜在的细胞靶点。
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Commensal microbe regulation of skin cells in disease

Human skin is the host to various commensal microbes that constitute a substantial microbial community. The reciprocal communication between these microbial inhabitants and host cells upholds both the morphological and functional attributes of the skin layers, contributing indispensably to microenvironmental and tissue homeostasis. Thus, disruption of the skin barrier or imbalances in the microbial communities can exert profound effects on the behavior of host cells. This influence, mediated by the microbes themselves or their metabolites, manifests in diverse outcomes. In this review, we examine existing knowledge to provide insight into the nuanced behavior exhibited by the microbiota on skin cells in health and disease states. These interactions provide insight into potential cellular targets for future microbiota-based therapies to prevent and treat skin disease.

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来源期刊
Cell host & microbe
Cell host & microbe 生物-微生物学
CiteScore
45.10
自引率
1.70%
发文量
201
审稿时长
4-8 weeks
期刊介绍: Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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