肠道微生物群在 2 型糖尿病的病理生理学和治疗中的核心作用

IF 20.6 1区 医学 Q1 MICROBIOLOGY Cell host & microbe Pub Date : 2024-08-14 DOI:10.1016/j.chom.2024.07.017
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引用次数: 0

摘要

我们肠道中的居民统称为肠道微生物群,由真菌、病毒和细菌菌株组成。这些微生物参与膳食化合物的发酵,并调节我们的适应性和先天性免疫系统。人们对肠道微生物群与 2 型糖尿病(T2DM)之间的相互影响以及它们在改变疗法以降低相关发病率和死亡率方面的作用知之甚少。在这篇综述中,我们旨在讨论与 T2DM 有关的肠道微生物菌株及其饮食衍生代谢物的现有文献。我们还探讨了肠道微生物群为有针对性地治疗 T2DM 提供的潜在诊断和治疗途径。根据患者的微生物群和临床指标,通过饮食和药物治疗,可以优化个性化治疗方案。
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The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes

The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as their role in modifying therapies to reduce associated morbidity and mortality. In this review, we aim to discuss the existing literature on gut microbial strains and their diet-derived metabolites involved in T2DM. We also explore the potential diagnostics and therapeutic avenues the gut microbiota presents for targeted T2DM management. Personalized treatment plans, driven by diet and medication based on the patient’s microbiome and clinical markers, could optimize therapy.

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来源期刊
Cell host & microbe
Cell host & microbe 生物-微生物学
CiteScore
45.10
自引率
1.70%
发文量
201
审稿时长
4-8 weeks
期刊介绍: Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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