Silvaticusins A-D：Isodon silvaticus 中的ent-kaurane diterpenoids 和一种含环丁烷的 ent-kaurane dimer。

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-08-15 DOI:10.1007/s13659-024-00465-9

Qi-Xiu Hai, Kun Hu, Su-Ping Chen, Yang-Yang Fu, Xiao-Nian Li, Han-Dong Sun, Hong-Ping He, Pema-Tenzin Puno

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摘要

从 Isodon silvaticus 的气生部分分离出了三种新的ent-kaurane 二萜类化合物 silvaticusins A-C (1-3)，以及一种新的ent-kaurane 二聚体 silvaticusin D (4)。这些新化合物的结构主要是通过对其核磁共振和质谱数据的综合分析而确定的。利用单晶 X 射线衍射和计算方法分别确定了化合物 1 和 4 的绝对构型。研究发现，化合物 2 和 3 对五种人类肿瘤细胞系（HL-60、A-549、SMMC-7721、MDA-MB-231 和 SW-480）具有显著的细胞毒性作用，IC50 值从 1.27 ± 0.08 到 7.52 ± 0.33 μM。

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Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus

Three new ent-kaurane diterpenoids, silvaticusins A–C (1–3), along with a new ent-kaurane dimer silvaticusin D (4) were isolated from the aerial parts of Isodon silvaticus. The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data. The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods, respectively. Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW-480), with IC₅₀ values spanning from 1.27 ± 0.08 to 7.52 ± 0.33 μM.