3-岩藻糖在健康影响和生产方面的最新进展。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-08-14 DOI:10.1007/s00203-024-04104-2

Zhihui Du, Zeyu Li, Cuie Guang, Yingying Zhu, Wanmeng Mu

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摘要

人乳低聚糖（HMOs）已被公认为婴儿发育的黄金标准。作为公认安全的人乳寡糖之一，3-岩藻糖(3-FL)是人乳寡糖领域的核心三糖；然而，与研究广泛的 2'-岩藻糖相比，它受到的关注相对较少。本综述旨在全面总结 3-FL 对健康的影响，包括对肠道微生物群增殖、抗菌作用、免疫调节、抗病毒保护和大脑成熟的影响。此外，还讨论了 3-FL 的商业应用和监管审批情况。最后，对 3-FL 的大规模生产方法进行了有条理的介绍，旨在提供一份全面的指南，重点介绍当前的优化策略和面临的挑战。

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Recent advances of 3-fucosyllactose in health effects and production

Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2′-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.