HDAC3 在行动：扩大在炎症和炎症性疾病中的作用

IF 5.9 1区生物学 Q2 CELL BIOLOGY Cell Proliferation Pub Date : 2024-08-14 DOI:10.1111/cpr.13731

Ruyuan He, Zhuokun He, Tianyu Zhang, Bohao Liu, Minglang Gao, Ning Li, Qing Geng

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引用次数: 0

摘要

炎症是众多生理和病理过程的基础，推动着各种疾病的发生和发展。组蛋白去乙酰化酶 3（HDAC3）是组蛋白去乙酰化酶超家族中一种重要的染色质修饰蛋白，它通过酶促组蛋白修饰发挥转录抑制作用，以维护机体的正常生理功能、生长和发育。HDAC3 具有酶和非酶活性，在调节与炎症反应和相关疾病有关的各种转录因子方面发挥着关键作用。本综述探讨了 HDAC3 参与炎症反应的情况，同时探讨了其作为治疗炎症疾病靶点的治疗潜力，从而为临床应用提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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HDAC3 in action: Expanding roles in inflammation and inflammatory diseases.

Inflammation serves as the foundation for numerous physiological and pathological processes, driving the onset and progression of various diseases. Histone deacetylase 3 (HDAC3), an essential chromatin-modifying protein within the histone deacetylase superfamily, exerts its transcriptional inhibitory role through enzymatic histone modification to uphold normal physiological function, growth, and development of the body. With both enzymatic and non-enzymatic activities, HDAC3 plays a pivotal role in regulating diverse transcription factors associated with inflammatory responses and related diseases. This review examines the involvement of HDAC3 in inflammatory responses while exploring its therapeutic potential as a target for treating inflammatory diseases, thereby offering valuable insights for clinical applications.

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.