FINRISK 队列中肠道微生物群与事故性骨折之间的关系。

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-08-14 DOI:10.1038/s41522-024-00530-8
Louise Grahnemo, Oleg Kambur, Leo Lahti, Pekka Jousilahti, Teemu Niiranen, Rob Knight, Veikko Salomaa, Aki S Havulinna, Claes Ohlsson
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引用次数: 0

摘要

肠道微生物群(GM)可调节骨量,但其与骨折事故的关系尚不清楚。我们在大型 FINRISK 2002 队列(n = 7043,1092 例骨折病例,中位随访时间为 18 年)中使用 Cox 回归模型来确定肠道微生物群的组成是否与骨折的发生有关。阿尔法多样性越高,骨折风险越低(香农指数每增加一个标准差,危险比 [HR] 为 0.92,95% 置信区间为 0.87-0.96)。就贝塔多样性而言,第一个主成分与骨折风险有关(艾奇逊距离,HR 0.90,0.85-0.96)。在预定义的系统分析中,我们发现变形菌的相对丰度与骨折风险的增加有关(HR 1.14,1.07-1.20),而泛酸菌的相对丰度与骨折风险的降低有关(HR 0.90,0.85-0.96)。蛋白质细菌门内的探索性子分析表明,伽马蛋白质细菌的相对丰度越高,骨折风险越高。功能性分析表明,与氨基酸代谢和脂多糖生物合成相关的通路与骨折风险有关。蛋白细菌的相对丰度与氨基酸代谢途径相关,而再生菌的相对丰度与丁酸合成途径相关。总之,全球基因组的整体组成与骨折事件有关。蛋白质细菌,尤其是伽马蛋白质细菌的相对丰度与骨折风险的增加有关,而Tenericutes的相对丰度与骨折风险的降低有关。功能性分析表明,已知的调节骨骼健康的途径可能是这些关联的基础。
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Associations between gut microbiota and incident fractures in the FINRISK cohort.

The gut microbiota (GM) can regulate bone mass, but its association with incident fractures is unknown. We used Cox regression models to determine whether the GM composition is associated with incident fractures in the large FINRISK 2002 cohort (n = 7043, 1092 incident fracture cases, median follow-up time 18 years) with information on GM composition and functionality from shotgun metagenome sequencing. Higher alpha diversity was associated with decreased fracture risk (hazard ratio [HR] 0.92 per standard deviation increase in Shannon index, 95% confidence interval 0.87-0.96). For beta diversity, the first principal component was associated with fracture risk (Aitchison distance, HR 0.90, 0.85-0.96). In predefined phyla analyses, we observed that the relative abundance of Proteobacteria was associated with increased fracture risk (HR 1.14, 1.07-1.20), while the relative abundance of Tenericutes was associated with decreased fracture risk (HR 0.90, 0.85-0.96). Explorative sub-analyses within the Proteobacteria phylum showed that higher relative abundance of Gammaproteobacteria was associated with increased fracture risk. Functionality analyses showed that pathways related to amino acid metabolism and lipopolysaccharide biosynthesis associated with fracture risk. The relative abundance of Proteobacteria correlated with pathways for amino acid metabolism, while the relative abundance of Tenericutes correlated with pathways for butyrate synthesis. In conclusion, the overall GM composition was associated with incident fractures. The relative abundance of Proteobacteria, especially Gammaproteobacteria, was associated with increased fracture risk, while the relative abundance of Tenericutes was associated with decreased fracture risk. Functionality analyses demonstrated that pathways known to regulate bone health may underlie these associations.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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