女性不孕症中 DNA 损伤和修复的分子调控:系统综述。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-08-14 DOI:10.1186/s12958-024-01273-z
Xiuhua Xu, Ziwei Wang, Luyi Lv, Ci Liu, Lili Wang, Ya-Nan Sun, Zhiming Zhao, Baojun Shi, Qian Li, Gui-Min Hao
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引用次数: 0

摘要

DNA 损伤是影响配子发生和胚胎发育的关键因素。DNA 的完整性和稳定性是女性成功受孕、胚胎发育、怀孕和生育健康后代的基础。衰老、活性氧、放疗和化疗往往会导致卵母细胞 DNA 损伤、卵巢储备功能减退和妇女不孕。随着不孕不育人群的增加,人们越来越需要研究不孕不育相关疾病与 DNA 损伤和修复之间的关系。研究人员尝试了各种方法来减少卵母细胞中的 DNA 损伤并增强其 DNA 修复能力,试图保护卵母细胞。在这篇综述中,我们总结了在多囊卵巢综合征、子宫内膜异位症、卵巢储备功能减退和卵巢囊肿等不孕不育疾病中 DNA 损伤反应机制的最新研究进展,这对生育力保存具有重要意义。
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Molecular regulation of DNA damage and repair in female infertility: a systematic review.

DNA damage is a key factor affecting gametogenesis and embryo development. The integrity and stability of DNA are fundamental to a woman's successful conception, embryonic development, pregnancy and the production of healthy offspring. Aging, reactive oxygen species, radiation therapy, and chemotherapy often induce oocyte DNA damage, diminished ovarian reserve, and infertility in women. With the increase of infertility population, there is an increasing need to study the relationship between infertility related diseases and DNA damage and repair. Researchers have tried various methods to reduce DNA damage in oocytes and enhance their DNA repair capabilities in an attempt to protect oocytes. In this review, we summarize recent advances in the DNA damage response mechanisms in infertility diseases such as PCOS, endometriosis, diminished ovarian reserve and hydrosalpinx, which has important implications for fertility preservation.

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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
期刊最新文献
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