回顾性综述:我们使用基于粘合剂的色素性病变检测法评估疑似黑色素瘤皮肤病变的经验。

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI:10.1097/DAD.0000000000002759
Shay Van Sambeek, Eric Friedlander, Willmar D Patino
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引用次数: 0

摘要

背景:作为全国最大的拥有内部病理实验室的皮肤病学团体之一,我们发现,除了活检和切除外,使用粘附性色素性病变检测(ABPLA)进行中度风险或高风险检测的数量也显著增加:报告我们的临床经验,并独立确认我们使用该 ABPLA(色素性病变检测,DermTech 公司,加利福尼亚州圣迭戈)的结果与检测制造商完成的验证研究结果一致:方法:对我们的电子病历进行回顾性审查,以了解 ABPLA 的结果、相应的组织病理学结果和可用的临床随访结果,并对其进行统计分析:结果:在回顾电子病历后,我们发现在 14 个月的时间里,我们为黑色素瘤色素病变进行了 893 次 ABPLA 检测。在已完成的 893 例 ABPLA 中,有 161 例是在得出初步检测结果后进行活检和切除的。我们还记录了更多的临床随访数据,用于对该检测的性能和准确性进行统计分析:局限性:被报告为黑色素瘤低风险的病变中,有相应组织病理学结果的病变数量较少,这限制了我们对该检测方法性能的评估。此外,由于临床随访时间不足或一些患者失去了随访机会,可能还有一些黑色素瘤没有被识别出来:根据我们的经验,这种 ABPLA 检测黑色素瘤的灵敏度为 92.0%,特异性为 79.5%,阳性预测值为 16.9%,阴性预测值为 99.5%。
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A Retrospective Review: Our Experience With an Adhesive-Based Pigmented Lesion Assay Used to Evaluate Cutaneous Lesions Suspicious for Melanoma.

Background: Being one of the largest dermatology groups in the country with an in-house pathology laboratory, we have seen a significant increase in the number of adhesive-based pigmented lesion assays (ABPLAs) in addition to biopsies and excisions following a moderate-risk or high-risk result with this test.

Objective: To report our clinical experience and independently confirm that our results with this ABPLA (Pigmented lesion assay, DermTech. San Diego, CA) are consistent with the results of the validation studies completed by the test manufacturer.

Methods: A retrospective review of our electronic medical records for results of ABPLAs, corresponding histopathologic results and available clinical follow-up, along with their statistical analysis was completed.

Results: After reviewing our electronic medical records, we found that 893 ABPLAs for pigmented lesions concerning for melanoma were obtained in a period of 14 months. Of the 893 ABPLAs completed, 161 biopsies and excisions were performed after the initial results of these assays. Additional clinical follow-up data were recorded and used for the statistical analysis of the performance and accuracy of this test.

Limitations: The small number of lesions reported as low risk for melanoma with corresponding histopathologic results limits our evaluation of the performance of this test. In addition, there may have been some melanomas that were not identified because the duration of the clinical follow-up was insufficient or because some patients were lost to follow-up.

Conclusion: In our experience this ABPLA has a sensitivity of 92.0%, a specificity of 79.5%, a positive predictive value of 16.9%, and a negative predictive value of 99.5% for the detection of melanoma.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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