{"title":"有氧训练和药膏对关节挛缩症患者活动范围、von Willebrand因子、血管内皮因子和股动脉血流动力学的影响：大鼠模型。","authors":"Palida Maimaiti, Jiaojiao Shu, Tianyu Miao, Nuerbiya Keqike, Asiguli Tuersun, Ruiqi Yang, Ningning Wang","doi":"10.1177/10998004241274290","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture.</p><p><strong>Methods: </strong>A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups (<i>n</i> = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively.</p><p><strong>Results: </strong>After fixator removal, ROM for EG group was lower than that of the NC group (<i>p</i> < .01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups (<i>p</i> < .05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups.</p><p><strong>Conclusion: </strong>Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"17-27"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aerobic Training and Ointment Effect on range of motion, von Willebrand factor, vascular endothelial factor and Femoral Artery Hemodynamics in Joint Contracture: A Rat Model.\",\"authors\":\"Palida Maimaiti, Jiaojiao Shu, Tianyu Miao, Nuerbiya Keqike, Asiguli Tuersun, Ruiqi Yang, Ningning Wang\",\"doi\":\"10.1177/10998004241274290\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture.</p><p><strong>Methods: </strong>A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups (<i>n</i> = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively.</p><p><strong>Results: </strong>After fixator removal, ROM for EG group was lower than that of the NC group (<i>p</i> < .01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups (<i>p</i> < .05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups.</p><p><strong>Conclusion: </strong>Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics.</p>\",\"PeriodicalId\":93901,\"journal\":{\"name\":\"Biological research for nursing\",\"volume\":\" \",\"pages\":\"17-27\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological research for nursing\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/10998004241274290\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological research for nursing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/10998004241274290","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的采用大鼠模型，研究包括有氧训练和药膏在内的多学科康复训练对关节挛缩大鼠的ROM、vWF、VEGF含量和股动脉血流动力学的影响：将 44 只 Wistar 大鼠分为正常对照组（NC，8 只）和实验组（EG）。通过外固定器为 EG 组大鼠建立关节挛缩模型。移除固定器后，32 只大鼠被进一步分为 MC 组、SC 组、RE 组和 SR 组（n = 8）。在 42 天的干预前后，分别使用 X 射线成像、ELISA 和彩色多普勒超声测量了大鼠的 ROM、vWF、VEGF、PS、ED 和 RI：取出固定器后，EG 组的 ROM 低于 NC 组（P < .01）。干预后，SR、RE 和 SC 组的 ROM 均有所改善。SR组的vWF和VEGF水平低于MC组、SC组和RE组（P＜0.05），与NC组相似。SR 组和 RE 组的 PS 值高于 MC 组和 SC 组。SR组的RI值高于NC组和MC组：结论：本研究中采用的多学科康复疗法可协同治疗关节挛缩。结论：本研究采用的多学科康复治疗可协同治疗关节挛缩，改善关节的活动度，降低血管内皮生长因子和血管内皮生长因子的含量，改善股动脉血流动力学。
Aerobic Training and Ointment Effect on range of motion, von Willebrand factor, vascular endothelial factor and Femoral Artery Hemodynamics in Joint Contracture: A Rat Model.
Objective: Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture.
Methods: A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups (n = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively.
Results: After fixator removal, ROM for EG group was lower than that of the NC group (p < .01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups (p < .05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups.
Conclusion: Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics.
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