Marianne Eijkemans, Monique Mommers, Margreet W Harskamp-van Ginkel, Tanja G M Vrijkotte, Johnny Ludvigsson, Åshild Faresjö, Anna Bergström, Sandra Ekström, Veit Grote, Berthold Koletzko, Klaus Bønnelykke, Anders Ulrik Eliasen, Peter Bager, Mads Melbye, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Ana Cristina Santos, Liesbeth Duijts, Sara M Mensink-Bout, Claudia Flexeder, Sibylle Koletzko, Tamara Schikowski, Merete Åse Eggesbø, Virissa Lenters, Guillermo Fernández-Tardón, Mikel Subiza-Perez, Judith Garcia-Aymerich, Mónica López-Vicente, Jordi Sunyer, Maties Torrent, Ferran Ballester, Cecily Kelleher, John Mehegan, Andrea von Berg, Gunda Herberth, Marie Standl, Claudia E Kuehni, Eva S L Pedersen, Maria Jansen, Ulrike Gehring, Jolanda M A Boer, Graham Devereux, Steve Turner, Ville Peltola, Hanna Lagström, Hazel M Inskip, Katharine C Pike, Geertje W Dalmeijer, Cornelis K van der Ent, Carel Thijs
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引用次数: 0
摘要
目的：在一项大型合作研究中，调查幼儿期体力活动（PA）和久坐行为与日后哮喘和肺功能下降的关系：在一项大型合作研究中，调查儿童早期体育活动（PA）和久坐行为与儿童后期哮喘和肺功能下降之间的关系：设计：对合作出生队列的纵向数据进行汇集，采用荟萃分析法对不同队列的特定估计值进行分析，并对所有队列的个体参与者数据进行分析：欧洲 26 个出生队列中 0-18 岁的儿童：主要结果测量：主要结果测量：基于调查问卷的当前哮喘情况和 6-18 岁时通过肺活量测定法（1 秒用力呼气容积（FEV1）、FEV1/用力肺活量）测量的肺功能：结果：3-5 岁时基于调查问卷和加速度测量的活动量和久坐行为与 6-18 岁时的哮喘无关（以小时/天计的活动量调整 OR 为 1.01，95% CI 为 0.98 至 1.04；以小时/天计的久坐行为调整 OR 为 1.03，95% CI 为 0.99 至 1.07）。在任何年龄段，PA 都与肺功能无关。对久坐行为和肺功能的分析结果不一致：结论：6 岁前运动量的减少和久坐行为的增加与儿童期哮喘的发生无关。
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.
Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.
Design: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.
Setting: Children aged 0-18 years from 26 European birth cohorts.
Participants: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.
Main outcome measure: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years.
Results: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.
Conclusions: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
期刊介绍：
BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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