利用激光表面工程钛合金植入物治疗心血管疾病的可能性

Andries MTHISI, Abimbola Patricia Idowu POPOOLA, Lehlogonolo Rudolf KANYANE, Sadiq Abiola RAJI, Nicholus MALATJI
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引用次数: 0

摘要

心血管疾病主要伤害和缩短了全世界无数人的生命。尽管心脏移植手术和其他医疗程序可以帮助心血管疾病患者延长寿命,但寻找合适的供体和治疗费用是迫使患者寻找侵入性较小和费用较低的疗法的障碍。合成生物材料(如钛基植入物)的使用提供了另一条可能治愈和再生心脏的途径。然而,在大多数生物医学案例中,钛基植入物都存在与表面相关的局限性,使其无法发挥潜力。多年来,与表面相关的不足通常是通过使用不同的表面改性技术制造具有更好性能的涂层来解决的。这些技术包括物理气相沉积、等离子喷涂、溶胶-凝胶和激光熔覆等。然而,利用激光改变心脏植入物表面的探索仍是一个需要进一步研究的课题。本研究综述了具有良好耐腐蚀性和生物相容性的功能涂层的发展情况,旨在推断在钛基心血管植入物上应用此类涂层的可能性,从而减轻这种疾病的负担。
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The possibility of using laser surface engineered titanium alloy implants as a treatment for cardiovascular diseases

Cardiovascular disorders primarily harm and shorten the lives of countless individuals worldwide. Even while surgical heart transplants and other medical procedures can help people with cardiovascular disease live longer, finding the right donor and the expense of therapy are obstacles that force patients to look for less intrusive and less expensive therapies. The use of synthetic biomaterials, such as titanium-based implants, offers an alternate path with the potential to heal and regenerate the heart. However, in most biomedical cases titanium-based implants are accompanied by surface related limitations which deter them from fulfilling their potential. Over the years, surface related shortfalls are usually addressed by fabrication of coatings exhibiting better properties using different sorts of surface modification techniques. These techniques include physical vapor depositions, plasma spraying, sol-gel and laser cladding etc. However, the exploration of employing lasers to alter the surface of cardiac based implants remains a subject that needs further research. In this work, the developments of functional coatings exhibiting good corrosion resistance and better biocompatibility are reviewed with the aim to deduce the possibility of applying such coatings on titanium based cardiovascular implants thereby alleviating burdens of this disease.

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来源期刊
Biomedical engineering advances
Biomedical engineering advances Bioengineering, Biomedical Engineering
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审稿时长
59 days
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