Hongliu Yu , Pengyu Hao , Panpan Si , Bing Wang , Qiying Shen , Hongliang Zhu , Wenxin Lin , Quan Hu
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A Mn-based metal-organic framework Mn-CPP for combined chemodynamic therapy and chemotherapy
A Mn-based metal-organic framework Mn-CPP was synthesized and showed excellent chemodynamic therapy (CDT) effect. DOX was selected and loaded into Mn-CPP obtaining DOX@Mn-CPP to improve the therapeutic properties. DOX@Mn-CPP exhibited better drug release behaviors in the tumor environment than that in normal environment. Besides, the material displayed good biocompatibility to L929 cells and significant effect of lethality on 4T1 cells and Hela cells. The successful fabrication of DOX@Mn-CPP provided the potential application for the combination therapy of chemodynamic therapy and chemotherapy.
期刊介绍：
The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds.
Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome.
The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.
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