Xiaoguang Hou, Yibo He, Guobing Liu, Shuguang Chen, Hongcheng Shi
{"title":"SPECT/CT 成像：量化脊柱和骨盆中的 99mTc-MDP 浓度。","authors":"Xiaoguang Hou, Yibo He, Guobing Liu, Shuguang Chen, Hongcheng Shi","doi":"10.1007/s12149-024-01967-9","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of <sup>99m</sup>Tc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.</p><h3>Methods</h3><p>Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with <sup>99m</sup>Tc-MDP were enrolled in this retrospective study. The mean SUV (SUV<sub>mean</sub>) of 4962 spinal and pelvic bones was calculated based on the patients’ body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUV<sub>bw</sub>, SUV<sub>lbm</sub>, SUV<sub>bmc</sub>, SUV<sub>bsa</sub>, and SUV<sub>bmi</sub>, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.</p><h3>Results</h3><p>The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUV<sub>bw</sub>, 3.555 ± 1.517 for SUV<sub>lbm</sub>, 0.163 ± 0.071 for SUV<sub>bmc</sub>, 0.124 ± 0.052 for SUV<sub>bsa</sub>, and 1.668 ± 0.732 for SUV<sub>bmi</sub>. In general, SUV<sub>bsa</sub> had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUV<sub>bsa</sub> was influenced only by age, BMI, and CT values independently. The effects of these variables on SUV<sub>bsa</sub> were all smaller than those on conventional SUV<sub>bw</sub>.</p><h3>Conclusions</h3><p>The SUVs of <sup>99m</sup>Tc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUV<sub>bsa</sub> exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"933 - 942"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SPECT/CT imaging: quantifying 99mTc-MDP concentration in the spine and pelvis\",\"authors\":\"Xiaoguang Hou, Yibo He, Guobing Liu, Shuguang Chen, Hongcheng Shi\",\"doi\":\"10.1007/s12149-024-01967-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of <sup>99m</sup>Tc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.</p><h3>Methods</h3><p>Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with <sup>99m</sup>Tc-MDP were enrolled in this retrospective study. The mean SUV (SUV<sub>mean</sub>) of 4962 spinal and pelvic bones was calculated based on the patients’ body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUV<sub>bw</sub>, SUV<sub>lbm</sub>, SUV<sub>bmc</sub>, SUV<sub>bsa</sub>, and SUV<sub>bmi</sub>, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.</p><h3>Results</h3><p>The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUV<sub>bw</sub>, 3.555 ± 1.517 for SUV<sub>lbm</sub>, 0.163 ± 0.071 for SUV<sub>bmc</sub>, 0.124 ± 0.052 for SUV<sub>bsa</sub>, and 1.668 ± 0.732 for SUV<sub>bmi</sub>. In general, SUV<sub>bsa</sub> had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUV<sub>bsa</sub> was influenced only by age, BMI, and CT values independently. The effects of these variables on SUV<sub>bsa</sub> were all smaller than those on conventional SUV<sub>bw</sub>.</p><h3>Conclusions</h3><p>The SUVs of <sup>99m</sup>Tc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUV<sub>bsa</sub> exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\"38 12\",\"pages\":\"933 - 942\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-024-01967-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-024-01967-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
SPECT/CT imaging: quantifying 99mTc-MDP concentration in the spine and pelvis
Objective
This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of 99mTc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.
Methods
Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with 99mTc-MDP were enrolled in this retrospective study. The mean SUV (SUVmean) of 4962 spinal and pelvic bones was calculated based on the patients’ body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUVbw, SUVlbm, SUVbmc, SUVbsa, and SUVbmi, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.
Results
The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUVbw, 3.555 ± 1.517 for SUVlbm, 0.163 ± 0.071 for SUVbmc, 0.124 ± 0.052 for SUVbsa, and 1.668 ± 0.732 for SUVbmi. In general, SUVbsa had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUVbsa was influenced only by age, BMI, and CT values independently. The effects of these variables on SUVbsa were all smaller than those on conventional SUVbw.
Conclusions
The SUVs of 99mTc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUVbsa exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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