日本急性细菌性前列腺炎的氟喹诺酮耐药性和临床特征:日本尿路感染研究小组的一项多中心研究。

IF 1.9 4区 医学 Q3 INFECTIOUS DISEASES Journal of Infection and Chemotherapy Pub Date : 2024-08-14 DOI:10.1016/j.jiac.2024.08.012
Masahiro Matsumoto, Ryoichi Hamasuna, Koichiro Wada, Takuya Sadahira, Katsumi Shigemura, Kouki Maeda, Yoshiki Hiyama, Yoshikazu Togo, Seiji Nagasawa, Kazuaki Yamanaka, Kazuyoshi Shigehara, Kanao Kobayashi, Haruki Tsuchiya, Jun Miyazaki, Tohru Nakagawa, Kiyohito Ishikawa, Satoshi Takahashi, Naohiro Fujimoto, Shingo Yamamoto
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引用次数: 0

摘要

目的:这项多中心研究旨在分析氟喹诺酮类药物(FQ)耐药性的风险因素,并阐明日本急性细菌性前列腺炎(ABP)的临床特征:这项多中心研究旨在分析氟喹诺酮(FQ)耐药性的风险因素,并明确日本急性细菌性前列腺炎(ABP)的临床特征:对2017年1月至12月期间参与日本尿路感染研究小组的13家医疗机构临床诊断为急性细菌性前列腺炎的124例患者进行回顾性研究:在纳入本研究的 124 例患者中,37 例为门诊患者,87 例为住院患者。ABP发病前的主要基础疾病为严重排尿困难、尿潴留、经尿道操作、留置导尿管和经直肠前列腺活检(TRBx)。主要症状为发热(≥ 37.5°C)、前列腺触痛、排尿困难、排尿疼痛、尿潴留和大血尿。14 名患者出现菌血症。3 名患者出现前列腺脓肿。大肠埃希菌是主要病原菌,占 48%(51/106)。33%的患者(17/51)检出耐氟喹大肠杆菌,12%的患者(6/51)检出产扩谱β-内酰胺酶大肠杆菌。TRBx(几率比 [OR] = 48.60,95% 置信区间 [CI]:5.49-430.00, p < 0.001)和住院病人状态(OR = 29.00, 95% CI: 1.95-430.00, p = 0.014)是检出耐 FQ 细菌的风险因素:结论:耐 FQ 细菌的检出率明显高于 TRBx ABP 和住院患者。这些发现对 ABP 的管理和抗菌治疗具有重要意义,尤其是 TRBx ABP,应将其视为一个独立的类别。
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Fluoroquinolone resistance and clinical characteristics of acute bacterial prostatitis in Japan: A multicenter study by the Japanese research group for urinary tract infection.

Objective: This multicenter study aimed to analyze the risk factors for fluoroquinolone (FQ) resistance and to clarify the clinical characteristics of acute bacterial prostatitis (ABP) in Japan.

Methods: A total of 124 patients clinically diagnosed with ABP at 13 medical institutions participating in the Japanese Research Group for Urinary Tract Infection between January and December 2017 were retrospectively reviewed.

Results: Of the 124 patients included in this study, 37 were outpatients, and 87 were inpatients. The main underlying medical conditions before the onset of ABP were severe dysuria, urinary retention, transurethral manipulation, indwelling urinary catheter, and transrectal prostate biopsy (TRBx). The main symptoms were fever (≥37.5 °C), prostate tenderness, dysuria, micturition pain, urinary retention, and macrohematuria. Bacteremia was observed in 14 patients. Prostatic abscess was observed in three patients. Escherichia coli was the predominant organism, accounting for 48 % (51/106). FQ-resistant E. coli was detected in 33 % (17/51), and extended-spectrum beta-lactamase-producing E. coli in 12 % (6/51). TRBx (odds ratio [OR] = 48.60, 95 % confidence interval [CI]: 5.49-430.00, p < 0.001) and inpatient status (OR = 29.00, 95 % CI: 1.95-430.00, p = 0.014) were risk factors for the detection of FQ-resistant bacteria.

Conclusions: The detection rate of FQ-resistant bacteria was significantly higher with TRBx ABP and inpatient status. These findings have important implications for the management of ABP and antimicrobial treatment, especially for TRBx ABP, which should be considered a separate category.

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来源期刊
Journal of Infection and Chemotherapy
Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
4.10
自引率
4.50%
发文量
303
审稿时长
47 days
期刊介绍: The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.
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