混合茶通过调节肠道微生物菌群改善 T2DM。

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI:10.1007/s11130-024-01222-6
Sui Liu, Xinyue Dai, Jinqi Zhao, Xuwen Zhang, Mingzhi Zhu, Kunbo Wang, Donghe Fu
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引用次数: 0

摘要

越来越多的证据表明,2型糖尿病(T2DM)与肠道微生物菌群失调密切相关,而肠道微生物菌群失调可以通过饮食干预得到改善。为了获得更好的风味,我们将四种天然植物产品,包括巴戟天、茯砖茶、毛蕊花和石蒜,混合制成混合茶产品。混合茶还被认为具有出色的药理活性。因此,本研究对混合茶对 T2DM 的改善作用及其机制进行了研究。结果表明,混合茶提取物能有效减轻以高脂肪和高蔗糖饮食喂养的 T2DM 小鼠的葡萄糖和脂质代谢相关紊乱症状。此外,混合茶提取物的干预还能显著减轻肠道微生物群失调,有助于碳水化合物水解和利用的类杆菌和固缩菌的数量显著增加,而致病菌如变形杆菌的数量则显著减少。某些参与能量代谢的核心微生物,包括Ruminococcaceae_UCG-005、Butyricimonas、Roseburia、Oscillibacter、[Eubacterium]_nodatum_group、Muribaculaceae、Prevotellaceae UCG 001,也在混合茶提取物的作用下得到改善。总之,我们的研究结果表明,混合茶可通过调节肠道微生物菌群改善 T2DM。混合茶可作为治疗 T2DM 和肠道微生物菌群失调的新型功能饮料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Blended Tea Ameliorates T2DM via Modulation of Gut Microflora.

Increasing evidences suggest that type 2 diabetes mellitus (T2DM) is closely related to gut microflora dysbiosis, which can be improved by dietary intervention. Four natural plant products, including Cyclocarya paliurus, Fu brick tea, Ampelopsis grossedentata, and Lithocarpus litseifolius, were blended to form a blended tea product for obtaining the better flavor. The blended tea was also expected to have excellent pharmacological activity. Therefore, the ameliorative effect of blended tea on T2DM and underlying mechanisms were studied in this study. The results showed that the blended tea extract effectively attenuated the symptoms of glucose and lipid metabolism-related disorders in T2DM mice fed by high-fat and high-sucrose diet. Furthermore, blended tea extract intervention significantly attenuated gut microbiota dysbiosis, the abundance of bacteria such as Bacteroidetes and Firmicutes, which aid in the hydrolysis and utilization of carbohydrates, significantly increased, while the abundance of pathogenic bacteria such as Proteobacteria significantly decreased. Certain core microorganisms involved in energy metabolism, including Ruminococcaceae_UCG-005, Butyricimonas, Roseburia, Oscillibacter, [Eubacterium]_nodatum_group, Muribaculaceae, Prevotellaceae UCG 001, were also found to be improved by blended tea extract. Collectively, our results demonstrated that the blended tea may ameliorate T2DM through modulation of gut microflora. The blended tea may serve as novel functional drink for the treatment of T2DM and dysbiosis of gut microbiota.

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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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