Toll样受体信号中的多糖体--结合并统治一切。

IF 3.2 4区 医学 Q3 CELL BIOLOGY Immunology & Cell Biology Pub Date : 2024-08-19 DOI:10.1111/imcb.12816
Carmen D Mathmann, Thomas E Schultz, Leslie C Domínguez Cadena, Antje Blumenthal
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引用次数: 0

摘要

Toll 样受体(TLR)是一种先天性免疫传感器,能感知病原体和内源性危险信号的存在。TLR 激活会导致保守的细胞内信号事件,从而协调炎症和抗微生物防御。虽然 TLR 信号关键成分的特性和相互作用已得到公认,但这些主要是细胞膜蛋白的物理连接方式却不甚明了。为了激活保守的细胞内信号事件,大多数 TLR 与适配器 MyD88(髓样分化主要反应 88)结合,后者组装成高阶蛋白复合物--myddosomes。Fisch 等人在最近发表的论文中提出了证据,证明低聚 myddosom 脱离了启动 TLR,进化成更大的支架,不仅能动态组装近端,还能组装执行 TLR-MyD88 信号通路整个级联所需的远端细胞膜元件。随着时间的推移,TLR 信号衰减,粘多糖体也会逐渐招募自噬机制,介导粘多糖体的清除。这些发现扩展了目前对 TLR 信号的理解,将粘多糖体定位为物理组装 TLR-MyD88 依赖性细胞内信号级联的关键执行者和调节者的核心结构元素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Myddosomes in Toll-like receptor signaling—one to bind and rule them all

Toll-like receptors (TLRs) are innate immune sensors for the presence of pathogens and endogenous danger signals. TLR activation results in conserved intracellular signaling events that orchestrate inflammation and antimicrobial defense. While the identity and interplay of key TLR signaling components are well established, how these largely cytosolic proteins are physically connected is not well understood. For the activation of conserved intracellular signaling events, most TLRs engage the adapter MyD88 (myeloid differentiation primary response 88), which assembles into higher-order protein complexes, myddosomes. In their recent publication, Fisch et al. present evidence that oligomeric myddosomes detach from initiating TLRs and evolve into larger scaffolds that dynamically assemble not only proximal but also distal cytosolic elements required to execute the entire cascade of the TLR–MyD88 signaling pathway. Coinciding with decline in TLR signaling over time, myddosomes progressively recruit autophagy machinery that mediates myddosome clearance. These findings expand the current understanding of TLR signaling by positioning myddosomes as the central structural element that physically assembles the key executors and regulators of TLR–MyD88-dependent intracellular signaling cascades.

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来源期刊
Immunology & Cell Biology
Immunology & Cell Biology 医学-免疫学
CiteScore
7.50
自引率
2.50%
发文量
98
审稿时长
4-8 weeks
期刊介绍: The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.
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