Alternaria 物种对某些次级代谢物的生物转化以及生物转化产物在制药、食品和农业方面的应用。

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-08-19 DOI:10.1007/s13659-024-00469-5

Babalwa Tembeni, Olusola Emmanuel Idowu, Rachid Benrkia, Salima Boutahiri, Opeyemi Joshua Olatunji

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引用次数: 0

摘要

生物转化是分子在生物催化剂或酶的作用下发生改变的过程，也是生物体因接触分子而发生新陈代谢改变的过程。微生物生物转化是天然产物药物发现的一个重要过程，因为新型化合物是通过生物合成产生的。此外，生物转化产物还能提高化合物的药效、溶解性，降低细胞毒性，并有助于了解结构与活性的关系。这些无懈可击的发现的推动力之一与细胞色素 P450 单氧化酶的存在有关，这种酶存在于哺乳动物、细菌和真菌等所有生物体内。许多真菌菌株都被用于生物转化不同化合物，并有相关报道。本综述重点介绍利用交链孢属真菌作为生物催化剂对天然产物化合物进行生物转化的研究。在温和的条件下，Alternaria 菌可促进有利于立体选择性和区域选择性的反应。此外，本综述还讨论了微生物生物转化产品及其在食品、制药和农业领域的应用。

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Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products

Biotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the metabolic alterations that occur in organisms from exposure to the molecules. Microbial biotransformation is an important process in natural product drug discovery as novel compounds are biosynthesised. Additionally, biotransformation products offer compounds with improved efficacy, solubility, reduced cytotoxic and allows for the understanding of structure activity relationships. One of the driving forces for these impeccable findings are associated with the presence of cytochrome P450 monooxygenases that is present in all organisms such as mammals, bacteria, and fungi. Numerous fungal strains have been used and reported for their ability to biotransform different compounds. This review focused on studies using Alternaria species as biocatalysts in the biotransformation of natural product compounds. Alternaria species facilitates reactions that favour stereoselectivity, regioselectivity under mild conditions. Additionally, microbial biotransformation products, their application in food, pharmaceutical and agricultural sector is discussed in this review.