与嗜酸性粒细胞食管炎相比，淋巴细胞性食管炎的临床特征、内窥镜检查结果和治疗效果。

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY American Journal of Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-08-20 DOI:10.14309/ajg.0000000000003046

Pierfrancesco Visaggi, Edoardo Savarino, Giulio Del Corso, Naoimh Herlihy, Matteo Ghisa, Jason M Dunn, Emanuele Marciano, Terry Wong, Michael Green, Nicola de Bortoli, Sebastian Zeki

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引用次数: 0

摘要

导言：淋巴细胞性食管炎和嗜酸性粒细胞性食管炎（LyE和EoE）是免疫介导的食管疾病。研究人员将淋巴细胞性食管炎和嗜酸性粒细胞性食管炎的临床特征、内镜检查结果和治疗效果与嗜酸性粒细胞性食管炎进行了比较：这是一项国际回顾性研究，对象是在欧洲三个中心登记的成年人。我们记录了基线时的临床特征和内镜检查结果，以及LyE和EoE患者治疗后的症状、组织学和内镜检查结果：结果：与59名EoE患者相比，35名LyE患者的人口统计学特征、临床表现、合并症和内镜检查结果存在很大差异。LyE患者对质子泵抑制剂（PPIs）的反应普遍较低：讨论：LyE在临床上不同于EoE，但治疗反应的差异需要进一步研究。

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Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared With Eosinophilic Esophagitis.

Introduction: Lymphocytic esophagitis (LyE) and eosinophilic esophagitis (EoE) are immune-mediated esophageal diseases. Clinical characteristics, endoscopic findings, and treatment outcomes of LyE were compared with EoE.

Methods: This was an international retrospective study on adults enrolled at 3 centers in Europe. We recorded clinical characteristics and endoscopy findings at baseline and symptoms, histology, and endoscopy outcomes after treatment of patients with LyE and EoE.

Results: Demographics, clinical presentation, comorbidities, and endoscopy findings were largely different in 35 patients with LyE compared with 59 patients with EoE. Proton pump inhibitor response was generally lower in LyE.

Discussion: LyE is clinically different from EoE, but differences in treatment response need further investigation.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.