利用混合 PET/MRI 技术研究脑部病变中钆增强与[18 F]氟胸苷摄取量之间的关系。

IF 3.5 2区 医学 Q2 ONCOLOGY Cancer Imaging Pub Date : 2024-08-19 DOI:10.1186/s40644-024-00761-0
Tomáš Rohan, Petr Hložanka, Marek Dostál, Tereza Kopřivová, Tomáš Macek, Václav Vybíhal, Hiroko Jeannette Martin, Andrea Šprláková-Puková, Miloš Keřkovský
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引用次数: 0

摘要

背景:评估和比较[18F]FLT-PET与ceMRI对脑肿瘤或其他病灶患者的诊断能力:评估和比较[18F]FLT-PET与ceMRI对脑肿瘤或其他局灶性病变患者的诊断能力。方法:121名疑似脑肿瘤患者或脑肿瘤术后患者(61名女性,60名男性,平均年龄37.3岁,范围1-80岁)被纳入这项回顾性研究。所有患者都接受了应用钆造影剂的[18F]FLT-PET/MRI检查。其中 118 名患者通过组织病理学或随访得到最终诊断。整个研究组的ceMRI和[18F]FLT-PET结果一致。此外,还计算了ceMRI和[18F]FLT-PET在区分高级别肿瘤与低级别肿瘤、高级别肿瘤与低级别肿瘤以及非肿瘤病变和区分高级别肿瘤与所有其他已核实病变方面的敏感性和特异性:结果:119 个病例(98%)的[18F]FLT-PET 和 ceMRI 结果一致。如果将对比度增强和[18F]FLT 摄取作为高级别肿瘤的标志,则对 64 例经核实的胶质瘤患者进行更仔细的分析,PET 和 ceMRI 在区分低级别肿瘤和高级别肿瘤方面的敏感性和特异性相同(分别为 90% 和 84%)。在通过肉眼评估区分高级别肿瘤与低级别肿瘤和非肿瘤病因病变(如炎性病变或治疗后病变)的 93 例亚组患者中,PET 和 ceMRI 的灵敏度均为 90%,而 PET 的特异性(61%)略高于 ceMRI(57%)。通过接收器操作特征分析,当肿瘤 SUVmax 临界值设定为 0.9 g/ml 时,敏感性和特异性分别为 82% 和 74%:我们的研究表明,[18F]FLT 积聚与 ceMRI 上可见的对比度增强之间的相关性普遍很高,两种模式在区分高级别肿瘤与低级别肿瘤和其他病因病变方面的诊断率相当。
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The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI.

Background: To evaluate and compare the diagnostic power of [18F]FLT-PET with ceMRI in patients with brain tumours or other focal lesions.

Methods: 121 patients with suspected brain tumour or those after brain tumour surgery were enroled in this retrospective study (61 females, 60 males, mean age 37.3 years, range 1-80 years). All patients underwent [18F]FLT-PET/MRI with gadolinium contrast agent application. In 118 of these patients, a final diagnosis was made, verified by histopathology or by follow-up. Agreement between ceMRI and [18F]FLT-PET of the whole study group was established. Further, sensitivity and specificity of ceMRI and [18F]FLT-PET were calculated for differentiation of high-grade vs. low-grade tumours, high-grade vs. low-grade tumours together with non-tumour lesions and for differentiation of high-grade tumours from all other verified lesions.

Results: [18F]FLT-PET and ceMRI findings were concordant in 119 cases (98%). On closer analysis of a subset of 64 patients with verified gliomas, the sensitivity and specificity of both PET and ceMRI were identical (90% and 84%, respectively) for differentiating low-grade from high-grade tumours, if the contrast enhancement and [18F]FLT uptake were considered as hallmarks of high-grade tumour. For differentiation of high-grade tumours from low-grade tumours and lesions of nontumorous aetiology (e.g., inflammatory lesions or post-therapeutic changes) in a subgroup of 93 patients by visual evaluation, the sensitivity of both PET and ceMRI was 90%, whereas the specificity of PET was slightly higher (61%) compared to ceMRI (57%). By receiver operating characteristic analysis, the sensitivity and specificity were 82% and 74%, respectively, when the threshold of SUVmax in the tumour was set to 0.9 g/ml.

Conclusion: We demonstrated a generally very high correlation of [18F]FLT accumulation with contrast enhancement visible on ceMRI and a comparable diagnostic yield in both modalities for differentiating high-grade tumours from low-grade tumours and lesions of other aetiology.

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来源期刊
Cancer Imaging
Cancer Imaging ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
7.00
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology. The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include: Breast Imaging Chest Complications of treatment Ear, Nose & Throat Gastrointestinal Hepatobiliary & Pancreatic Imaging biomarkers Interventional Lymphoma Measurement of tumour response Molecular functional imaging Musculoskeletal Neuro oncology Nuclear Medicine Paediatric.
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