以线粒体修复为目标的纳米酶在疾病治疗中的应用。

IF 4.1 2区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of biotechnology Pub Date : 2024-08-17 DOI:10.1016/j.jbiotec.2024.08.008
Yuan Zhang , Shuxian Ma , Wenguang Chang , Wanpeng Yu , Lei Zhang
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引用次数: 0

摘要

线粒体是生物氧化和物质代谢的关键场所,在维持细胞内平衡方面发挥着重要作用。当线粒体发生氧化损伤或功能障碍时,就会危害机体,导致各种与活性氧(ROS)相关的疾病。因此,针对线粒体的疗法是治疗多种疾病的一种策略。许多纳米酶可以模拟抗氧化酶,从而消除 ROS,缓解线粒体功能障碍。针对线粒体电子传递链(ETC)的治疗方法和药物已成为治疗线粒体呼吸链紊乱导致的氧化应激相关疾病的有效方法。因此,能够调节线粒体 ETC 平衡的纳米酶已成为治疗氧化应激相关疾病的有效治疗药物。此外,利用纳米酶的可控性和可修改性,用 TPP、SS-31 肽和线粒体通透膜肽对其进行修饰,可消除 ROS 并修复线粒体功能。专门针对线粒体的纳米酶是治疗 ROS 相关疾病的有力工具。我们讨论了治疗各种疾病的线粒体靶向纳米酶的设计策略,以便在未来开发出更有效的纳米酶工具来治疗 ROS 相关疾病。
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Nanozymes targeting mitochondrial repair in disease treatment

Mitochondria are crucial sites for biological oxidation and substance metabolism and plays a vital role in maintaining intracellular homeostasis. When mitochondria undergo oxidative damage or dysfunction, they can harm the organism, leading to various reactive oxygen species (ROS)-related diseases. Therefore, therapies targeting mitochondria are a strategy for treating multiple diseases. Many nanozymes can mimic antioxidant enzymes, which enables them to eliminate ROS to mitigate mitochondrial dysfunction. The therapeutic approaches and drugs targeting the mitochondrial electron transport chain (ETC) have emerged as effective treatments for oxidative stress-related diseases resulting from mitochondrial respiratory chain disorders. Therefore, nanozymes that can regulate homeostasis in the mitochondrial ETC have emerged as effective therapeutic agents for treating oxidative stress-related diseases. In addition, benefit from the controllability and modifiability of nanozymes, their modification with TPP, SS-31 peptide, and mitochondrial permeability membrane peptide to eliminate ROS and repair mitochondrial function. The nanozymes that specifically target mitochondria are powerful tools for the treatment of ROS-associated disorders. We discussed the design strategies pertaining to mitochondrion-targeted nanozymes to treat various diseases to develop more efficacious nanozyme tools for the treatment of ROS-related diseases in the future.

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来源期刊
Journal of biotechnology
Journal of biotechnology 工程技术-生物工程与应用微生物
CiteScore
8.90
自引率
2.40%
发文量
190
审稿时长
45 days
期刊介绍: The Journal of Biotechnology has an open access mirror journal, the Journal of Biotechnology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal provides a medium for the rapid publication of both full-length articles and short communications on novel and innovative aspects of biotechnology. The Journal will accept papers ranging from genetic or molecular biological positions to those covering biochemical, chemical or bioprocess engineering aspects as well as computer application of new software concepts, provided that in each case the material is directly relevant to biotechnological systems. Papers presenting information of a multidisciplinary nature that would not be suitable for publication in a journal devoted to a single discipline, are particularly welcome.
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