注意力缺陷多动障碍青少年患牙周炎的风险：一项针对 81,055 名参与者的队列研究。

IF 2.7 3区医学 Q2 PSYCHIATRY Journal of Attention Disorders Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI:10.1177/10870547241273093

Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Wen-Liang Lo, Mu-Hong Chen

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引用次数: 0

摘要

研究目的以往的研究表明，患有注意力缺陷多动障碍（ADHD）的儿童口腔卫生状况不佳。然而，ADHD与牙周炎之间的关系仍不清楚：方法：2001 年至 2011 年间，共有 16211 名患有多动症的青少年和 162110 名年龄和性别匹配的对照组参加了研究。为确定牙周炎的发生情况，对参与者进行了跟踪调查，直至 2011 年底。对吸烟、糖尿病和抑郁症等干扰因素进行了评估，并在Cox回归模型中进行了调整：结果：与对照组相比，患有多动症的青少年（HR：2.29）更容易在晚年患上牙周炎。此外，我们还观察到了阿托西汀（HR：0.42）对多动症青少年牙周炎风险的有利影响。然而，鉴于本研究中服用阿托西汀的儿童样本较少（n = 290），因此应谨慎解释这一发现：多动症是导致牙周炎的一个独立风险因素。结论：多动症是牙周炎发展的独立风险因素，应密切关注多动症青少年的口腔健康。今后有必要对牙周炎和多动症之间的共同病理机制进行研究。

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Risk of Periodontitis in Adolescents With Attention Deficit Hyperactivity Disorder: A Cohort Study of 81,055 Participants.

Objectives: Previous studies have demonstrated poor oral hygiene in children with attention deficit hyperactivity disorder (ADHD). However, the association between ADHD and periodontitis is still unclear.

Methods: In all, 16,211 adolescents with ADHD and 162,110 age- and sex-matched controls participated in the study between 2001 and 2011. To identify the occurrence of periodontitis, the participants were followed up till the end of 2011. Confounding factors, including smoking, diabetes, and depressive disorder, were assessed and adjusted in the Cox regression models.

Results: Adolescents with ADHD (HR: 2.29) were more likely to develop periodontitis later in life than controls. We additionally observed the beneficial effect of atomoxetine (HR: 0.42) on the periodontitis risk among adolescents with ADHD. However, this finding should be interpreted cautiously given the small sample (n = 290) of children taking atomoxetine in the present study.

Conclusions: ADHD is an independent risk factor for subsequent periodontitis development. Oral health should be closely monitored in adolescents with ADHD. Future investigation of the shared pathomechanisms between periodontitis and ADHD is warranted.

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.