将含油红酵母作为生产油脂化学品和有价值化合物的多功能底盘:当前的进展和前景。

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-08-18 DOI:10.1016/j.biotechadv.2024.108432
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引用次数: 0

摘要

要实现向以工业生物制造为基础的未来循环生物经济的过渡,就必须为可持续的化学和燃料生产开发高效、多功能的微生物平台。最近,由于非模式微生物具有广泛的底物范围和较强的抗应激能力,人们对将其作为优质生物制造平台进行工程化研究的兴趣日益浓厚。在这些非常规微生物中,属于红酵母属的红酵母已成为生产特种化学品(如油脂化学品、有机酸、脂肪酸衍生物、萜类化合物和其他有价值的化合物)的有前途的工业底盘。遗传和代谢工程技术的进步,加上系统生物学分析,大大提高了红酵母的生产能力。这些发展也扩大了这些酵母菌可利用或合成的底物和产品的范围。本综述全面探讨了当前红酵母研究工作和最新进展。它包括对可用底物的探索、利用多组学数据进行系统分析、建立基因组尺度模型、开发高效分子工具、鉴定遗传因子以及生产各种工业相关生物产品的工程方法。此外,还讨论了利用系统生物学和合成生物学方法改善底物转化和产品形成的策略,以及将红酵母改进为更多功能生物技术底盘以促进循环生物经济的未来方向和前景。本综述旨在为这一快速发展领域的进一步研究提供见解和方向。最终,利用红酵母的能力将在为下一代可持续生物经济铺平道路方面发挥至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Engineering oleaginous red yeasts as versatile chassis for the production of oleochemicals and valuable compounds: Current advances and perspectives

Enabling the transition towards a future circular bioeconomy based on industrial biomanufacturing necessitates the development of efficient and versatile microbial platforms for sustainable chemical and fuel production. Recently, there has been growing interest in engineering non-model microbes as superior biomanufacturing platforms due to their broad substrate range and high resistance to stress conditions. Among these non-conventional microbes, red yeasts belonging to the genus Rhodotorula have emerged as promising industrial chassis for the production of specialty chemicals such as oleochemicals, organic acids, fatty acid derivatives, terpenoids, and other valuable compounds. Advancements in genetic and metabolic engineering techniques, coupled with systems biology analysis, have significantly enhanced the production capacity of red yeasts. These developments have also expanded the range of substrates and products that can be utilized or synthesized by these yeast species. This review comprehensively examines the current efforts and recent progress made in red yeast research. It encompasses the exploration of available substrates, systems analysis using multi-omics data, establishment of genome-scale models, development of efficient molecular tools, identification of genetic elements, and engineering approaches for the production of various industrially relevant bioproducts. Furthermore, strategies to improve substrate conversion and product formation both with systematic and synthetic biology approaches are discussed, along with future directions and perspectives in improving red yeasts as more versatile biotechnological chassis in contributing to a circular bioeconomy. The review aims to provide insights and directions for further research in this rapidly evolving field. Ultimately, harnessing the capabilities of red yeasts will play a crucial role in paving the way towards next-generation sustainable bioeconomy.

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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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