人类 T 滤泡辅助细胞及其对过敏、恶性肿瘤和 IgG4 相关疾病中 IgE 和 IgG4 生成的影响。

IF 6.2 2区 医学 Q1 ALLERGY Allergology International Pub Date : 2024-08-19 DOI:10.1016/j.alit.2024.07.005
Mitsuhiro Akiyama, Waleed Alshehri, Sho Ishigaki, Koichi Saito, Yuko Kaneko
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引用次数: 0

摘要

人类 T 滤泡辅助细胞(Tfh)在协调 B 细胞分化、成熟和免疫球蛋白类别转换方面发挥着至关重要的作用。最近的研究强调,Bcl-6 + Tfh 细胞不仅存在于二级淋巴器官中,而且还存在于炎症部位的三级淋巴结构中,从而强调了它们在疾病发病机制中的关键作用。此外,T细胞受体谱分析还发现,Tfh细胞可在病变部位、淋巴结和外周血之间转移。在 Tfh 亚群中,Tfh2 细胞已成为驱动 B 细胞产生 IgE 和 IgG4 的核心协调者。它们在过敏、恶性肿瘤和 IgG4 相关疾病中的关键作用凸显了它们对平衡炎症和免疫耐受的深远影响。本综述介绍了人类 Tfh 细胞的分子特征、Tfh 亚群的分化途径、Tfh 亚群诱导 IgE 和 IgG4 生成的机制,以及它们在过敏、恶性肿瘤和 IgG4 相关疾病中的临床意义。
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Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease.

Human T follicular helper (Tfh) cells play a crucial role in orchestrating B cell differentiation, maturation, and immunoglobulin class switching. Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at inflammatory sites, emphasizing their pivotal role in disease pathogenesis. Furthermore, Tfh cells have been found to transit between lesion sites, lymph nodes, and peripheral blood, as revealed by T cell receptor repertoire analysis. Among Tfh subsets, Tfh2 cells have emerged as central orchestrators in driving the production of IgE and IgG4 from B cells. Their critical role in diseases such as allergy, malignancy, and IgG4-related disease highlights their profound impact on balancing inflammation and immune tolerance. Our current review provides the molecular characteristics of human Tfh cells, the differentiation pathways of Tfh subsets, mechanisms by which Tfh subsets induce IgE and IgG4 production, and their clinical implications in allergy, malignancy, and IgG4-related disease.

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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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