针对轻度阿尔茨海默氏症患者及其护理人员的认知行为治疗(CBTAC):随机对照试验结果。

IF 2.8 3区 医学 Q3 GERIATRICS & GERONTOLOGY Aging & Mental Health Pub Date : 2024-08-20 DOI:10.1080/13607863.2024.2393748
Simon Forstmeier, Andreas Maercker, Livia Bohli, Egemen Savaskan, Tanja Roth
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引用次数: 0

摘要

研究目的本研究旨在评估针对轻度阿尔茨海默氏痴呆症(AD)患者及其照顾者的多成分心理治疗方案对抑郁症和相关神经精神症状的影响:以认知行为疗法(CBT)为基础的治疗每周进行25次,包括行为激活、行为管理、对照顾者的干预、回忆、夫妻辅导和认知重组。41 名参与者及其照顾者被随机分配到 CBT 组或对照组,对照组接受常规治疗(TAU)。治疗后 6 个月和 12 个月进行随访。主要结果是注意力缺失症患者的抑郁情况。次要结果是冷漠、其他神经精神症状、功能能力、生活质量以及与照顾者的关系质量:线性混合模型显示,在 12 个月的随访中,CBT 在临床医生评定的抑郁方面具有显著的统计学优势,且具有较大的效应大小(受试者内 d = 1.22,受试者间 d = 1.00)。自评抑郁的效应大小仅为中等,信息评定抑郁的效应大小较小。在临床医生评定的冷漠、人际关系质量和信息提供者评定的生活质量(QoL)方面,CBT 也有明显优势,但在其他神经精神症状或自我评定的 QoL 方面则没有:结论:研究结果非常鼓舞人心,支持进行充分的多中心研究:试验注册:ClinicalTrials.gov NCT01273272。注册日期:2011 年 1 月 3 日注册日期:2011 年 1 月 3 日
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Cognitive behavioural treatment for mild Alzheimer's patients and their caregivers (CBTAC): results of a randomised controlled trial.

Objectives: This study aimed to evaluate the effects of a multicomponent psychotherapy programme for people with mild Alzheimer's dementia (AD) and their caregivers on depression and related neuropsychiatric symptoms.

Method: The cognitive behavioural therapy (CBT)-based treatment consisted of 25 weekly sessions, including behavioural activation, behaviour management, interventions for the caregiver, reminiscence, couples counselling, and cognitive restructuring. 41 participants and their caregivers were randomised to either the CBT or the control group, which received treatment-as-usual (TAU). Follow-ups took place at 6 and 12 months posttreatment. The primary outcome was depression in the patient with AD. The secondary outcomes were apathy, other neuropsychiatric symptoms, functional abilities, quality of life, and quality of the relationship with the caregiver.

Results: Linear mixed models revealed a statistically significant superiority of CBT regarding clinician-rated depression at the 12-month follow-up with large effect sizes (within-subject d = 1.22, between-subject d = 1.00). Effect sizes were only moderate for self-rated depression and small for informant-rated depression. There was also a significant advantage for CBT regarding clinician-rated apathy, relationship quality, and informant-rated quality of life (QoL) but not for the other neuropsychiatric symptoms or self-rated QoL.

Conclusion: The results are very encouraging and support an adequately powered multicentre study.

Trial registration: ClinicalTrials.gov NCT01273272. Date of registration: 3 Jan 2011.

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来源期刊
Aging & Mental Health
Aging & Mental Health 医学-精神病学
CiteScore
7.00
自引率
2.90%
发文量
176
审稿时长
4-8 weeks
期刊介绍: Aging & Mental Health provides a leading international forum for the rapidly expanding field which investigates the relationship between the aging process and mental health. The journal addresses the mental changes associated with normal and abnormal or pathological aging, as well as the psychological and psychiatric problems of the aging population. The journal also has a strong commitment to interdisciplinary and innovative approaches that explore new topics and methods. Aging & Mental Health covers the biological, psychological and social aspects of aging as they relate to mental health. In particular it encourages an integrated approach for examining various biopsychosocial processes and etiological factors associated with psychological changes in the elderly. It also emphasizes the various strategies, therapies and services which may be directed at improving the mental health of the elderly and their families. In this way the journal promotes a strong alliance among the theoretical, experimental and applied sciences across a range of issues affecting mental health and aging. The emphasis of the journal is on rigorous quantitative, and qualitative, research and, high quality innovative studies on emerging topics.
期刊最新文献
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