基于抗程序性死亡-1抗体的联合疗法对中国晚期或转移性胃癌或胃食管交界癌的疗效和安全性:真实世界研究

IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2024-07-01 DOI:10.1177/00368504241272703
Yifan Gao, Haoqian Li, Lei Qiu, Hongtu Yuan, Qing Fan, Zuoxing Niu, Ligang Xing, Mingxing Li, Dandan Yuan
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引用次数: 0

摘要

目的:程序性死亡-1抗体联合化疗已被批准用于治疗(人表皮生长因子受体2阴性的局部晚期或转移性胃癌或胃食管交界癌)。本研究旨在分析抗程序性死亡-1抗体联合化疗或抗血管生成治疗在中国晚期或转移性胃癌或胃食管交界癌患者中的疗效和安全性:在2019年4月至2021年12月期间,共有122名患者接受了基于抗程序性死亡-1抗体的联合治疗。对临床结果和安全性进行了测量和分析:在整个队列中,中位总生存期为17.2个月,中位无进展生存期为10.9个月,中位反应持续时间为9.4个月。值得注意的是,一线患者未达到中位总生存期,中位无进展生存期为14.8个月,客观反应率为68.4%。在二线组中,中位总生存期、中位无进展生存期、中位反应持续时间和客观反应率分别为10.9个月、5.9个月、4.5个月和41.5%。28.2%的患者出现任何级别的治疗相关不良反应,主要影响血液和肝功能。3级或4级不良反应主要表现为天冬氨酸氨基转移酶、丙氨酸氨基转移酶水平升高,淋巴细胞和白细胞减少,以及贫血:我们队列中的患者在一线治疗中从抗程序性死亡-1抗体联合治疗中获得了临床获益,治疗相关的不良反应是可以接受的。抗程序性死亡-1抗体联合化疗或抗血管生成治疗对二线患者的益处应通过大型多中心随机对照临床试验进一步证实。
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Efficacy and safety of anti-programmed death-1 antibody-based combination therapy in advanced or metastatic gastric or gastroesophageal junction cancer in Chinese patients: A real-world study.

Purpose: Programmed death-1 antibody plus chemotherapy has gained approval for the treatment for (human epidermal growth factor receptor 2 negative locally advanced or metastatic gastric or gastroesophageal junction cancer. This study aims to analyze the efficacy and safety of anti-programmed death-1 antibody combined with chemo- or anti-angiogenesis therapy in Chinese patients with advanced or metastatic gastric or gastroesophageal junction cancer in a real-world setting.

Methods: In total, 122 patients treated with anti-programmed death-1 antibody-based combination therapy between April 2019 and December 2021 were encompassed. Clinical outcomes and safety profile were measured and analyzed.

Results: In the whole cohort, median overall survival was 17.2 months, median progression-free survival was 10.9 months, and median duration of response was 9.4 months. Notably, in the first-line patients, the median overall survival was not reached, median progression-free survival was 14.8 months, objective response rate was 68.4%. In the second-line group, median overall survival, median progression-free survival, median duration of response, and objective response rate were 10.9 months, 5.9 months, 4.5 months, and 41.5%, respectively. Treatment-related adverse events of any grade were observed in 28.2% of the overall cohort, primarily affecting the hematological and liver function. Grade 3 or 4 adverse events were mainly characterized by increased levels of aspartate aminotransferase, alanine aminotransferase, along with decreased lymphocyte and white blood cells, as well as anemia.

Conclusions: Patients in our cohort experienced a clinical benefit from anti-programmed death-1 antibody-combined treatment in first-line treatment settings, with acceptable treatment-related adverse events. The benefit of anti-programmed death-1 antibody combined with chemo- or anti-angiogenesis treatment to the second-line patients should be further confirmed by large multi-center randomized, controlled clinical trials.

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来源期刊
Science Progress
Science Progress Multidisciplinary-Multidisciplinary
CiteScore
3.80
自引率
0.00%
发文量
119
期刊介绍: Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.
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