Jorge Jorquera , Constanza Salas-Cossio , Juan Fernando Oyarzo , Constanza Pacheco , Margarita Del Favero , Montserrat Sánchez
{"title":"轻度和中度阻塞性睡眠呼吸暂停的治疗方案","authors":"Jorge Jorquera , Constanza Salas-Cossio , Juan Fernando Oyarzo , Constanza Pacheco , Margarita Del Favero , Montserrat Sánchez","doi":"10.1016/j.rmclc.2024.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>Obstructive sleep apnea (OSA) is a common disease that causes daytime symptoms, decreased quality of life, increased risk of cardio and cerebrovascular morbidity and mortality, neurocognitive impairments, and higher traffic accident rates. Continuous positive airway pressure therapy (CPAP) is highly effective and has been the treatment of choice for patients with severe disease and those with moderate disease accompanied by daytime symptoms and/or cardiovascular comorbidity. However, CPAP has limitations in terms of acceptance and treatment adherence. There are various treatment options available, such as weight loss, the use of oral devices, positional devices, surgery and emerging therapies like myofunctional therapy. These personalized treatments have shown promising results, particularly in patients with mild to moderate OSA or those seeking an effective alternative to standard treatment. It is increasingly recognized that OSA is a disorder with diverse risk factors, clinical presentations, pathophysiology, and comorbidities. A better understanding of patient heterogeneity will allow for more personalized treatment approaches and ensure the effectiveness of interventions through advanced and precision medicine. This review provides an overview of current approaches to non-surgical treatment of mild to moderate OSA in patients without an indication for CPAP treatment or who reject that option. Additionally, it proposes a therapeutic algorithm to guide the management of these patients.</p></div>","PeriodicalId":31544,"journal":{"name":"Revista Medica Clinica Las Condes","volume":"35 3","pages":"Pages 281-289"},"PeriodicalIF":0.2000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0716864024000385/pdfft?md5=7e7d24e906c7478b2b23d3d690d7edf7&pid=1-s2.0-S0716864024000385-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Opciones de tratamiento para la apnea obstructiva del sueño leve y moderada\",\"authors\":\"Jorge Jorquera , Constanza Salas-Cossio , Juan Fernando Oyarzo , Constanza Pacheco , Margarita Del Favero , Montserrat Sánchez\",\"doi\":\"10.1016/j.rmclc.2024.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Obstructive sleep apnea (OSA) is a common disease that causes daytime symptoms, decreased quality of life, increased risk of cardio and cerebrovascular morbidity and mortality, neurocognitive impairments, and higher traffic accident rates. Continuous positive airway pressure therapy (CPAP) is highly effective and has been the treatment of choice for patients with severe disease and those with moderate disease accompanied by daytime symptoms and/or cardiovascular comorbidity. However, CPAP has limitations in terms of acceptance and treatment adherence. There are various treatment options available, such as weight loss, the use of oral devices, positional devices, surgery and emerging therapies like myofunctional therapy. These personalized treatments have shown promising results, particularly in patients with mild to moderate OSA or those seeking an effective alternative to standard treatment. It is increasingly recognized that OSA is a disorder with diverse risk factors, clinical presentations, pathophysiology, and comorbidities. A better understanding of patient heterogeneity will allow for more personalized treatment approaches and ensure the effectiveness of interventions through advanced and precision medicine. This review provides an overview of current approaches to non-surgical treatment of mild to moderate OSA in patients without an indication for CPAP treatment or who reject that option. Additionally, it proposes a therapeutic algorithm to guide the management of these patients.</p></div>\",\"PeriodicalId\":31544,\"journal\":{\"name\":\"Revista Medica Clinica Las Condes\",\"volume\":\"35 3\",\"pages\":\"Pages 281-289\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0716864024000385/pdfft?md5=7e7d24e906c7478b2b23d3d690d7edf7&pid=1-s2.0-S0716864024000385-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Medica Clinica Las Condes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0716864024000385\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Medica Clinica Las Condes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0716864024000385","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
阻塞性睡眠呼吸暂停(OSA)是一种常见疾病,会导致日间症状、生活质量下降、心脑血管发病和死亡风险增加、神经认知障碍以及交通事故率升高。持续气道正压疗法(CPAP)非常有效,一直是重度患者和伴有白天症状和/或心血管合并症的中度患者的首选治疗方法。然而,CPAP 在接受度和治疗依从性方面存在局限性。目前有多种治疗方法可供选择,如减轻体重、使用口服装置、体位装置、手术以及肌功能疗法等新兴疗法。这些个性化疗法已显示出良好的效果,尤其是对轻度至中度 OSA 患者或寻求标准治疗有效替代方法的患者。人们越来越认识到,OSA 是一种具有不同风险因素、临床表现、病理生理学和合并症的疾病。更好地了解患者的异质性将有助于采用更加个性化的治疗方法,并通过先进的精准医学确保干预措施的有效性。本综述概述了目前针对无 CPAP 治疗指征或拒绝 CPAP 治疗的轻度至中度 OSA 患者的非手术治疗方法。此外,它还提出了一种治疗算法来指导这些患者的治疗。
Opciones de tratamiento para la apnea obstructiva del sueño leve y moderada
Obstructive sleep apnea (OSA) is a common disease that causes daytime symptoms, decreased quality of life, increased risk of cardio and cerebrovascular morbidity and mortality, neurocognitive impairments, and higher traffic accident rates. Continuous positive airway pressure therapy (CPAP) is highly effective and has been the treatment of choice for patients with severe disease and those with moderate disease accompanied by daytime symptoms and/or cardiovascular comorbidity. However, CPAP has limitations in terms of acceptance and treatment adherence. There are various treatment options available, such as weight loss, the use of oral devices, positional devices, surgery and emerging therapies like myofunctional therapy. These personalized treatments have shown promising results, particularly in patients with mild to moderate OSA or those seeking an effective alternative to standard treatment. It is increasingly recognized that OSA is a disorder with diverse risk factors, clinical presentations, pathophysiology, and comorbidities. A better understanding of patient heterogeneity will allow for more personalized treatment approaches and ensure the effectiveness of interventions through advanced and precision medicine. This review provides an overview of current approaches to non-surgical treatment of mild to moderate OSA in patients without an indication for CPAP treatment or who reject that option. Additionally, it proposes a therapeutic algorithm to guide the management of these patients.