Revista Medica Clinica Las Condes最新文献

Mucormicosis en cirugía maxilofacial. Una revisión de la literatura 上颌面手术中的粘菌病。文学评论

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.002

Víctor Herrera-Barraza DDS , Felipe Donoso-Rebolledo DDS, MEd , Javiera Morales-Romero DDS , Nicolás Ferrer-Valdivia DDS, MEd, OMR

Introduction

Mucormycosis is a low-prevalence fungal infection with high mortality, primarily affecting immunocompromised patients, such as diabetics and COVID-19 patients. In the maxillofacial region, it presents with facial pain, swelling, and ulcers, making early diagnosis and timely treatment crucial. The objective of this study is to perform a structured literature review on the implications of mucormycosis in maxillofacial surgery, focusing on its epidemiology, diagnostic approaches, and treatment strategies.

Materials and Methods

A narrative literature review was conducted using the keywords “Mucormycosis” AND “Maxillofacial Surgery” across the databases PubMed, SciELO, Scopus, ScienceDirect, and Google Scholar. Relevant articles published in the last 10 years, from January 2015 to March 2025, were included, focusing on the epidemiology, diagnosis, and treatment of mucormycosis in maxillofacial surgery.

Results

Rhino-orbito-cerebral mucormycosis (ROCM) is the most common form in maxillofacial surgery, particularly in patients with diabetes, those treated with immunosuppressive corticosteroids, and those affected by COVID-19. Diagnosis involves clinical history, imaging, and histopathological analysis, complemented by pharmacological and surgical treatments.

Conclusion

Mucormycosis is a complex and challenging condition in maxillofacial surgery, with high mortality. A multidisciplinary approach combining early diagnosis, surgical treatment, and appropriate antifungal therapy is essential to improve survival and reduce the sequelae of the infection.

毛霉病是一种低流行率、高死亡率的真菌感染，主要影响免疫功能低下的患者，如糖尿病患者和COVID-19患者。在颌面区域，它表现为面部疼痛、肿胀和溃疡，早期诊断和及时治疗至关重要。本研究的目的是对颌面部外科中毛霉菌病的意义进行结构化的文献回顾，重点是其流行病学，诊断方法和治疗策略。材料与方法以“Mucormycosis”和“Maxillofacial Surgery”为关键词，检索PubMed、SciELO、Scopus、ScienceDirect和谷歌Scholar等数据库，进行叙述性文献综述。纳入2015年1月至2025年3月近10年发表的相关文章，重点介绍颌面部外科毛霉菌病的流行病学、诊断和治疗。结果鼻-眶-脑毛霉菌病（ROCM）是颌面部外科手术中最常见的形式，尤其是糖尿病患者、免疫抑制糖皮质激素治疗患者和新冠肺炎患者。诊断包括临床病史、影像学和组织病理学分析，辅以药物和手术治疗。结论毛霉菌病是颌面部外科中一种复杂且具有挑战性的疾病，病死率高。早期诊断、手术治疗和适当的抗真菌治疗相结合的多学科方法对于提高生存率和减少感染的后遗症至关重要。

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引用次数: 0

“Star Travel” “星球旅行”

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.007

引用次数: 0

Distrofia fascioescapulohumeral en paciente octogenario: evaluación integral y efectividad de la kinesioterapia a largo plazo 80多岁患者的筋膜外皮营养不良：对运动疗法长期疗效的全面评估

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.11.004

Constanza Rivas-Sanhueza BKin , Rodrigo Muñoz-Cofré PhD , Fernando Valenzuela-Aedo MSc , Lydia Lera PhD , Pablo A. Lizana PhD

Fascioscapulohumeral dystrophy (FSHD) is one of the most common forms of muscular dystrophy. It mainly affects the muscles of the face, shoulder and upper arm. Symptoms usually appear between the ages of 10 and 26. They are often mild and worsen very slowly.

This article describes the morphologic and functional characteristics, evaluations, and interventions performed on an octogenarian older adult with DFEH.

Assessments were performed on the musculoskeletal, respiratory, and neurological systems, in addition to blood work, spirometry, palmar grip strength, and bioimpedance. Interventions included kinesiotherapy sessions two to three times per week for seven years, focusing on maintaining muscle strength, flexibility and aerobic capacity.

Initial assessment and reassessment showed a progressive decrease in muscle strength and joint mobility, muscle atrophy, as well as respiratory complications.

Systematic kinesiotherapy allowed maintaining muscle activity levels, preventing joint stiffness, and improving the patient's overall functionality. The results indicated a maintenance of functionality and quality of life, although limited by the progressive nature of FSHD.

筋膜肩肱骨营养不良症（FSHD）是最常见的肌肉营养不良症之一。它主要影响面部、肩部和上臂的肌肉。症状通常出现在10到26岁之间。它们通常是轻微的，恶化得很慢。这篇文章描述了形态学和功能特征，评估和干预执行对一个八十多岁的老年人DFEH。除了血液检查、肺活量测定、手掌握力和生物阻抗外，还对肌肉骨骼、呼吸和神经系统进行了评估。干预措施包括每周进行两到三次的运动疗法，持续七年，重点是保持肌肉力量、柔韧性和有氧能力。初步评估和再评估显示肌肉力量和关节活动度逐渐下降，肌肉萎缩，以及呼吸并发症。系统的运动疗法可以维持肌肉活动水平，防止关节僵硬，并改善患者的整体功能。结果表明，尽管FSHD的进行性受到限制，但功能和生活质量得到了维持。

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引用次数: 0

Tumor de Masson: presentación de un caso clínico y revisión bibliográfica 马森肿瘤：临床病例介绍和文献综述

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.004

Claudio Andrés Ñanco-Meléndez MD , María Beatriz Ramos-Alarcón MD , Karen Lissette Cobeña-Macías MD

Introduction

Masson's tumor is a rare non-neoplastic reactive process with a benign course and excellent prognosis. It should be highly suspected diagnostically, as it is often confused with malignant pathologies such as angiosarcoma.

Clinical Case

A 61-year-old man with a history of arterial hypertension consults for an asymptomatic solitary lesion in the left lower extremity of 10 years of evolution. Physical examination revealed a violaceous erythematous nodule with a vascular appearance and a brown center. Dermoscopy revealed a brown center of non-melanocytic appearance, with linear and globular vascular structures, associated with whitish nonspecific areas. An incisional biopsy was performed showing vascular spaces with papillary architecture, positive for CD34 and negative for AE1/AE3, a result compatible with intrapapillary endothelial hyperplasia. The study was complemented with magnetic resonance imaging that shows involvement of the dermoepidermal plane and partially the superficial subcutaneous cell.

Conclusion

It is essential to integrate the clinical picture, radiology and biopsy to achieve the diagnosis and extension of Masson's tumor. We believe it is useful to share this type of cases in order to familiarize ourselves with the diagnosis and increase the possibilities of diagnostic suspicion.

马森氏肿瘤是一种罕见的非肿瘤反应性肿瘤，具有良好的预后。在诊断上应高度怀疑，因为它常与恶性病理如血管肉瘤混淆。临床病例：一名61岁男性，有动脉高血压病史，因左下肢无症状单发病变发展10年而就诊。体格检查显示紫色红斑结节，呈血管性外观，中心呈棕色。皮肤镜检查显示非黑素细胞外观的棕色中心，线状和球状血管结构，与白色非特异性区域相关。切口活检显示血管间隙呈乳头状结构，CD34阳性，AE1/AE3阴性，结果与乳头内内皮增生一致。该研究辅以磁共振成像，显示真皮表皮平面和部分浅表皮下细胞受累。结论临床影像学、影像学和活检相结合对马松瘤的诊断和扩展至关重要。我们认为，分享这类病例是有益的，以便我们熟悉诊断并增加诊断怀疑的可能性。

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引用次数: 0

Comentarios sobre la declaración de uso de inteligencia artificial con una perspectiva de integridad académica en educación médica y ciencias de la salud 关于从医学教育和健康科学学术诚信角度宣布使用人工智能的意见

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.10.013

Paola Jackeline Vidal Polo , Jackeline Santa Cruz Astochad , Guillermo César Fernández

引用次数: 0

Formación en competencias informacionales e investigativas con el uso de IA en clases de bioética 在生物伦理学课程中使用人工智能进行信息和研究技能培训

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.005

Paulo López-Soto , Manuel Santos MD , Nolly Herrera , Carolina Williams PhD

Introduction

The Training Project in Informational and Research Competencies with AI in Bioethics emerges as an innovative initiative aimed at strengthening students’ research skills through the integration of artificial intelligence in their learning processes. Implemented as a pilot program, the project adopts a project-based learning approach in which students develop competencies through four work modules.

Materials and Methods

This mixed-methods study was carried out in three stages: theory, implementation, and analysis, within a bioethics course. A total of 33 students from various academic programs participated. Workshops were conducted on both traditional research methods and the use of AI tools (ChatGPT, Citavi, and Connected Papers), applied alternately. Validated questionnaires, interviews, and checklists were used. Quantitative analysis focused on grades and student perceptions, while qualitative analysis identified patterns through thematic coding using Dedoose.

Results

The findings reveal a positive perception of AI compared to a lower appreciation of traditional methods. The qualitative analysis highlighted categories reflecting both the benefits and challenges of each approach, including AI's efficiency and student resistance to change. While some students preferred traditional methods due to familiarity, AI proved effective in improving grades and research competencies.

Conclusion

The study concludes that a balanced integration of AI and traditional methods enhances learning in bioethics. This experience not only improves the quality of learning but also lays the groundwork for potential replication in other areas of higher education.

人工智能在生物伦理学中的信息和研究能力培训项目是一项创新举措，旨在通过将人工智能整合到学生的学习过程中来加强学生的研究技能。该项目作为试点项目实施，采用基于项目的学习方法，通过四个工作模块培养学生的能力。材料和方法本混合方法研究在生物伦理学课程中分三个阶段进行：理论、实施和分析。来自不同专业的33名学生参加了此次活动。举办了关于传统研究方法和人工智能工具（ChatGPT、Citavi和Connected Papers）交替应用的研讨会。使用了有效的问卷调查、访谈和核对表。定量分析侧重于成绩和学生的看法，而定性分析通过使用Dedoose进行主题编码来确定模式。研究结果表明，与传统方法的低评价相比，人们对人工智能的看法是积极的。定性分析强调了反映每种方法的好处和挑战的类别，包括人工智能的效率和学生对变革的抵制。虽然一些学生由于熟悉而更喜欢传统方法，但人工智能在提高成绩和研究能力方面被证明是有效的。结论人工智能与传统方法的平衡融合有助于生物伦理学的学习。这种经验不仅提高了学习质量，而且为高等教育其他领域的潜在复制奠定了基础。

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引用次数: 0

Prevalencia de polifarmacia en urgencias y criterios STOPP/START en personas de 65 y más años, en una institución de Bogotá, 2021 2021年波哥大一家机构65岁及以上老年人紧急情况和STOPP/START标准中的多药流行率

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.001

Angélica Mora-Cabrera MD , Yuly Guerrero-Muñoz MD , Héctor Salamanca-Gómez MD

Background

Population aging entails a greater burden of chronic diseases, increased need for medical care, and a higher risk of polypharmacy. This is a public health issue that has been insufficiently studied in emergency departments and is associated with significant negative consequences, particularly when medication use is inappropriate. The objective of this study was to determine the prevalence of polypharmacy and potentially inappropriate medications in the emergency department among individuals aged 65 and older at a University Hospital in Bogotá in 2021.

Materials and methods

A cross-sectional descriptive study was conducted through a review of medical records. Hospital admissions lasting more than 6 hours and evaluated by any specialty during their stay in the Emergency Department were included. Admissions to the ICU within the first 24 hours or records with incomplete data were excluded. A sample size was calculated using a 99% confidence level, and sociodemographic, diagnostic, and prescription-related variables were described.

Results

A total of 614 medical records were reviewed. The mean age was 75.5 years, and 55.9% were female. The overall prevalence of polypharmacy was 29%. The average number of diagnoses was 4.42. The maximum number of medications was 14, with a median of 7. A total of 1171 prescriptions were identified, of which 178 (53.7%) were classified as inappropriate according to STOPP/START criteria. The highest prevalence of inappropriate medications corresponded to cardiovascular system drugs.

Conclusions

The prevalence of polypharmacy and inappropriate medications is high in the emergency department. Implementing a systematic pharmaceutical evaluation upon emergency department admission for individuals aged 65 and older is recommended.

人口老龄化导致慢性病负担加重，医疗保健需求增加，多种用药风险增加。这是一个公共卫生问题，在急诊科尚未得到充分研究，并与严重的负面后果有关，特别是在药物使用不当时。本研究的目的是确定2021年波哥大一所大学医院 65岁及以上老年人在急诊科使用多种药物和可能不适当药物的流行情况。材料和方法通过对医疗记录的回顾进行横断面描述性研究。住院时间超过6小时并在急诊科住院期间由任何专业进行评估的患者也包括在内。排除前24小时内入住ICU或数据不完整的记录。使用99%的置信水平计算样本量，并描述社会人口学、诊断和处方相关变量。结果共查阅病历614份。平均年龄75.5岁，女性占55.9%。综合用药的总体患病率为29%。平均诊断次数为4.42例。最大用药数为14，中位数为7。共鉴定出1171张处方，其中178张（53.7%）按照STOPP/START标准归类为不适宜处方。不适当用药的发生率最高的是心血管系统药物。结论急诊科多药及用药不当的发生率较高。建议对65岁及以上患者急诊入院时进行系统的药物评价。

{"title":"Prevalencia de polifarmacia en urgencias y criterios STOPP/START en personas de 65 y más años, en una institución de Bogotá, 2021","authors":"Angélica Mora-Cabrera MD , Yuly Guerrero-Muñoz MD , Héctor Salamanca-Gómez MD","doi":"10.1016/j.rmclc.2025.12.001","DOIUrl":"10.1016/j.rmclc.2025.12.001","url":null,"abstract":"<div><h3>Background</h3><div>Population aging entails a greater burden of chronic diseases, increased need for medical care, and a higher risk of polypharmacy. This is a public health issue that has been insufficiently studied in emergency departments and is associated with significant negative consequences, particularly when medication use is inappropriate. The objective of this study was to determine the prevalence of polypharmacy and potentially inappropriate medications in the emergency department among individuals aged 65 and older at a University Hospital in Bogotá in 2021.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional descriptive study was conducted through a review of medical records. Hospital admissions lasting more than 6hours and evaluated by any specialty during their stay in the Emergency Department were included. Admissions to the ICU within the first 24hours or records with incomplete data were excluded. A sample size was calculated using a 99% confidence level, and sociodemographic, diagnostic, and prescription-related variables were described.</div></div><div><h3>Results</h3><div>A total of 614 medical records were reviewed. The mean age was 75.5 years, and 55.9% were female. The overall prevalence of polypharmacy was 29%. The average number of diagnoses was 4.42. The maximum number of medications was 14, with a median of 7. A total of 1171 prescriptions were identified, of which 178 (53.7%) were classified as inappropriate according to STOPP/START criteria. The highest prevalence of inappropriate medications corresponded to cardiovascular system drugs.</div></div><div><h3>Conclusions</h3><div>The prevalence of polypharmacy and inappropriate medications is high in the emergency department. Implementing a systematic pharmaceutical evaluation upon emergency department admission for individuals aged 65 and older is recommended.</div></div>","PeriodicalId":31544,"journal":{"name":"Revista Medica Clinica Las Condes","volume":"36 6","pages":"Pages 494-504"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Válvula aórtica cuadricúspide: reporte de caso y breve revisión 四头主动脉瓣：病例报告和简要回顾

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.11.002

Tamar Gaprindashvili MD, Zaza Katsitadze PhD, Rusudan Agladze PhD, Nino Nersezashvili MD

Quadricuspid aortic valve (QAV) is a rare congenital anomaly, often associated with aortic regurgitation. We present the case of a 64-year-old man with progressive dyspnea, diagnosed with QAV through intraoperative transesophageal echocardiography. A bioprosthetic aortic valve replacement was performed due to patient preference and risk factors. The objective of this article is to present a rare case of quadricuspid aortic valve associated with an anomalous right coronary artery, highlighting diagnostic challenges, surgical implications, and management lessons.

四尖瓣主动脉瓣（QAV）是一种罕见的先天性异常，通常与主动脉反流有关。我们报告一例64岁男性进行性呼吸困难，通过术中经食管超声心动图诊断为QAV。由于患者偏好和危险因素，我们进行了生物假体主动脉瓣置换术。本文的目的是提出一个罕见的病例四尖瓣主动脉瓣与异常右冠状动脉，突出诊断挑战，手术意义和管理经验。

引用次数: 0

Impacto de una intervención multimodal en el síndrome de dolor regional complejo con compromiso orofacial: un reporte de caso 多模式干预对涉及口面部的复杂区域疼痛综合征的影响：案例报告

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.12.003

Joan Peralta-Jara , Paula Espinoza-Mellado , Pedro Rojas-Román MSc , Felipe Rosales-Lillo MSc

Complex regional pain syndrome (CRPS) with orofacial involvement is a rare condition that can lead to persistent pain, functional impairment, and psychosocial impact. This case report describes the clinical evolution of a 52-year-old woman with CRPS affecting the left upper limb with extension to the orofacial region, and evaluates the effect of a multimodal intervention on pain, orofacial and swallowing function, and emotional status. The patient had a history of polytrauma following an accident in 2007. In 2023, she developed severe pain and autonomic symptoms meeting the Budapest criteria, and treatment with a sphenopalatine ganglion block was initiated. The clinical picture included limited mandibular mobility, dysphagia, and depressive symptoms.

A 12-week therapeutic program was implemented, including cognitive-behavioral therapy, speech-language pathology rehabilitation focused on swallowing, and maxillofacial physical therapy. Follow-up assessments included validated scales: kinesiophobia (Tampa Scale), depression (PHQ-9), pain (VAS and LANSS), mandibular function (JFLS-8), patient-specific functional perception (PSFS), mandibular mobility measured with a digital caliper, dysphagia severity (DRS), and swallowing self-perception (EAT-10).

After the intervention, improvements were observed across all outcome measures. Kinesiophobia decreased (42 to 28 pts), depressive symptoms lessened (15 to 9 pts), and pain was reduced (VAS 9 to 5; LANSS 26 to 10 pts). Mandibular functional limitation improved (33 to 19 pts), mouth opening increased (18 to 25 mm), and patient-specific functionality markedly improved (1.0 to 7.8 pts). Swallowing function also progressed, both in severity (DRS 4 to 6 pts) and self-perception (EAT-10 32 to 12 pts).

In conclusion, the multimodal intervention resulted in reduced pain, improved orofacial and swallowing function, and enhanced psychosocial well-being in a patient with CRPS and orofacial involvement.

伴有口面部受累的复杂区域疼痛综合征（CRPS）是一种罕见的疾病，可导致持续疼痛、功能障碍和社会心理影响。本病例报告描述了一名52岁女性CRPS患者的临床进展，CRPS影响到左上肢并延伸到口面部区域，并评估了多模式干预对疼痛、口面部和吞咽功能以及情绪状态的影响。患者在2007年的一次事故后有多发外伤史。2023年，她出现了严重的疼痛和符合布达佩斯标准的自主神经症状，并开始了蝶腭神经节阻滞治疗。临床表现包括下颌活动受限、吞咽困难和抑郁症状。实施了为期12周的治疗方案，包括认知行为治疗、以吞咽为重点的语言病理学康复和颌面物理治疗。随访评估包括经过验证的量表：运动恐惧症（坦帕量表）、抑郁（PHQ-9）、疼痛（VAS和LANSS）、下颌功能（JFLS-8）、患者特异性功能感知（PSFS）、用数字卡尺测量下颌活动度、吞咽困难严重程度（DRS）和吞咽自我感知（eating -10）。干预后，所有结果指标均有改善。运动恐惧症减少（42 - 28分），抑郁症状减轻（15 - 9分），疼痛减轻（VAS 9 - 5分；LANSS 26 - 10分）。下颌功能受限改善（33 - 19分），开口增加（18 - 25毫米），患者特异性功能显著改善（1.0 - 7.8分）。吞咽功能也有进展，包括严重程度（DRS 4 - 6分）和自我知觉（EAT-10 32 - 12分）。总之，多模式干预减少了CRPS患者的疼痛，改善了口面部和吞咽功能，并增强了患者的社会心理健康。

{"title":"Impacto de una intervención multimodal en el síndrome de dolor regional complejo con compromiso orofacial: un reporte de caso","authors":"Joan Peralta-Jara , Paula Espinoza-Mellado , Pedro Rojas-Román MSc , Felipe Rosales-Lillo MSc","doi":"10.1016/j.rmclc.2025.12.003","DOIUrl":"10.1016/j.rmclc.2025.12.003","url":null,"abstract":"<div><div>Complex regional pain syndrome (CRPS) with orofacial involvement is a rare condition that can lead to persistent pain, functional impairment, and psychosocial impact. This case report describes the clinical evolution of a 52-year-old woman with CRPS affecting the left upper limb with extension to the orofacial region, and evaluates the effect of a multimodal intervention on pain, orofacial and swallowing function, and emotional status. The patient had a history of polytrauma following an accident in 2007. In 2023, she developed severe pain and autonomic symptoms meeting the Budapest criteria, and treatment with a sphenopalatine ganglion block was initiated. The clinical picture included limited mandibular mobility, dysphagia, and depressive symptoms.</div><div>A 12-week therapeutic program was implemented, including cognitive-behavioral therapy, speech-language pathology rehabilitation focused on swallowing, and maxillofacial physical therapy. Follow-up assessments included validated scales: kinesiophobia (Tampa Scale), depression (PHQ-9), pain (VAS and LANSS), mandibular function (JFLS-8), patient-specific functional perception (PSFS), mandibular mobility measured with a digital caliper, dysphagia severity (DRS), and swallowing self-perception (EAT-10).</div><div>After the intervention, improvements were observed across all outcome measures. Kinesiophobia decreased (42 to 28 pts), depressive symptoms lessened (15 to 9 pts), and pain was reduced (VAS 9 to 5; LANSS 26 to 10 pts). Mandibular functional limitation improved (33 to 19 pts), mouth opening increased (18 to 25mm), and patient-specific functionality markedly improved (1.0 to 7.8 pts). Swallowing function also progressed, both in severity (DRS 4 to 6 pts) and self-perception (EAT-10 32 to 12 pts).</div><div>In conclusion, the multimodal intervention resulted in reduced pain, improved orofacial and swallowing function, and enhanced psychosocial well-being in a patient with CRPS and orofacial involvement.</div></div>","PeriodicalId":31544,"journal":{"name":"Revista Medica Clinica Las Condes","volume":"36 6","pages":"Pages 529-534"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tadalafilo en el manejo integral del crecimiento prostático benigno y la disfunción eréctil: una revisión comparativa frente a tamsulosina 他达拉非在良性前列腺生长和勃起功能障碍综合管理中的作用：与他苏拉素的比较综述

IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL

Revista Medica Clinica Las Condes

Pub Date : 2025-11-01 DOI: 10.1016/j.rmclc.2025.11.001

Itaf Bitar-Cedeño , Sebastian Estrada-Cortés , Kevin Estrada-Cortés , Andrea Saavedra-Álvarez PhD

Benign prostatic growth is a condition frequently associated with lower urinary tract symptoms and erectile dysfunction.

Objective

To comparatively evaluate the efficacy and safety of tadalafil versus tamsulosin in the comprehensive management of benign prostatic growth associated with erectile dysfunction.

Methods

A literature review of clinical evidence published in scientific databases was conducted, analyzing relevant studies between 2009 and 2024.

Results

Tadalafil demonstrated dual and significant efficacy in improving International Prostate Symptom Score (IPSS) (urinary symptoms) and erectile function, a benefit not observed with tamsulosin as monotherapy. Combination therapy with tamsulosin showed a significantly greater reduction in total IPSS (MD = −1.95; p < 0.0001), with a favorable safety profile for patients.

Conclusion

Tadalafil is positioned as a comprehensive therapeutic alternative, with dual effects on lower urinary tract symptoms and erectile function. Its anti-inflammatory and antiproliferative properties suggest a potential to slow the progression of benign prostatic growth, supporting its use as a first-line option when restoration of sexual function is also a priority in the patient's clinical presentation. However, the choice of treatment should be based on the individual characteristics of the patient.

良性前列腺增生通常与下尿路症状和勃起功能障碍有关。目的比较他达拉非与坦索罗辛综合治疗前列腺增生伴勃起功能障碍的疗效和安全性。方法对科学数据库中发表的临床证据进行文献回顾，分析2009 ~ 2024年的相关研究。结果他达拉非在改善国际前列腺症状评分（IPSS）（泌尿系统症状）和勃起功能方面表现出双重和显著的疗效，而坦索罗辛单药治疗没有观察到这种益处。与坦索罗辛联合治疗可显著降低总IPSS (MD = - 1.95; p < 0.0001)，对患者具有良好的安全性。结论他达拉非对下尿路症状和勃起功能具有双重疗效，是一种综合性的治疗方案。它的抗炎和抗增殖特性表明有可能减缓良性前列腺生长的进展，当性功能恢复也是患者临床表现的优先考虑时，支持其作为一线选择。然而，治疗的选择应基于患者的个体特征。

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引用次数: 0