光动力疗法对不可切除胆管癌外周免疫系统的影响

IF 3.1 3区 医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2024-08-20 DOI:10.1016/j.pdpdt.2024.104279
Xinqiang Wu , Xiaofeng Jiang , Zhaoyuan Liu , Ping Xue , Yubin Chen , Liangqi Cao , Zilong Wen , Yunqiang Tang
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引用次数: 0

摘要

背景光动力疗法(PDT)已逐渐成为一种治疗不可切除胆管癌(CCA)的有效方法。许多实验证明,光动力疗法能显著增强抗肿瘤免疫力。然而,PDT 对不可切除的 CCA 外周免疫系统的影响仍不清楚。方法在一项临床试验中,我们比较了 PDT+ 支架治疗和单纯支架治疗不可切除型 CCA 的围手术期和长期疗效,并检测了淋巴细胞(CD4+ T 细胞、CD8+ T 细胞、NK 细胞、B 细胞和 Treg 细胞)和免疫细胞的水平、B细胞和Treg细胞)和免疫相关细胞因子(IL-4、IL-6、IL-10、TNF-α、TGF-β、穿孔素、GM-CSF和IFN-γ)的水平,分析PDT对不可切除CCA外周免疫系统的影响。结果治疗前,所有免疫细胞和免疫相关细胞因子的水平在 PDT+ 支架组和单纯支架组之间无显著差异。CD8+ T 细胞的比例在 PDT 治疗后明显增加,但其他种类的淋巴细胞没有明显差异。结论PDT改变了不可切除CCA患者外周血中免疫细胞和免疫相关细胞因子的水平,可能与PDT治疗不可切除CCA的疗效有关。今后的研究可在这方面进行更深入的探讨,以探索如何更有效地利用 PDT 治疗不可切除的 CCA。
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Effect of photodynamic therapy on peripheral immune system for unresectable cholangiocarcinoma

Background

Photodynamic therapy (PDT) has been emerging as a promising treatment for unresectable cholangiocarcinoma (CCA). A number of experiments have demonstrated that PDT could enhance antitumor immunity significantly. However, the impact of PDT on peripheral immune system for unresectable CCA remains unclear.

Methods

In a clinical trial comparing the perioperative and long-term outcomes of PDT+stent treatment and stent alone treatment for unresectable CCA, we tested the levels of lymphocytes (CD4+ T cells, CD8+ T cells, NK cells, B cells and Treg cells) and immune-related cytokines (IL-4, IL-6, IL-10, TNF-α, TGF-β, perforin, GM-CSF and IFN-γ) in peripheral blood before and after PDT+stent treatment or stent alone treatment and analyzed the influence of PDT on peripheral immune system for unresectable CCA.

Results

Before treatment, the levels of all the immune cells and immune-related cytokines did not show significant differences between the PDT+stent group and stent alone group. The ratio of CD8+ T cells increased significantly after PDT treatment, but other kinds of lymphocytes did not show significant difference. Increased level of IL-6 and decreased level of perforin and TGF-β after PDT treatment were demonstrated, whereas no significant changes were found for other immune-related cytokines.

Conclusion

PDT altered the levels of immune cells and immune-related cytokines in the peripheral blood of unresectable CCA patients, potentially correlating with the therapeutic efficacy of PDT in unresectable CCA treatment. Future studies could delve deeper into this aspect to explore how PDT can be more effectively utilized in the management of unresectable CCA.

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来源期刊
CiteScore
5.80
自引率
24.20%
发文量
509
审稿时长
50 days
期刊介绍: Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
期刊最新文献
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