基因 IFIT1 与膳食铜诱导的绵羊黄脂病有关

Depeng Li, Juncai Fu
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摘要

在肉羊快速育肥和饲养过程中,绵羊黄脂病频繁发生。本研究旨在探讨绵羊黄脂病的初步发病机制。选取 18 只健康绵羊(4-5 月龄,34 ± 1 千克),随机分为三组:10 ppm 铜组、50 ppm 铜组和 100 ppm 铜组。实验结束后,对所有绵羊采集血液、肝脏、肾脏和脂肪组织样本,并测量各项指标。日粮中添加 50 和 100ppm 铜对绵羊的平均日增重、总胆固醇(TC)、甘油三酯(TG)和山梨醇脱氢酶没有显著影响,但对肝脏中的γ-谷氨酰转移酶、天冬氨酸氨基转移酶和丙氨酸氨基转移酶酶活性的影响显著增加,并增加了铜在肝脏中的积累。饲料中添加 50 和 100ppm 铜会对肝、肾和脂肪造成不同程度的病理损伤,并显著影响胴体脂肪的亮度、红度和黄度。50 ppm 铜组的绵羊在实验后期没有出现明显的黄脂病临床症状,但 100 ppm 铜组的绵羊出现了明显的黄脂病临床症状。绵羊肝脏转录组分析显示了与黄脂病相关的不同基因,并进行了与黄脂病相关的GO和KEGG分析,进一步的相关分析发现铜诱导的黄脂病的发生可能与基因IFIT1密切相关。
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The gene IFIT1 is associated with dietary copper-induced yellow fat disease in sheep

In the process of rapid fattening and rearing of meat sheep, yellow fat disease of sheep occurs frequently. This study aims to investigate the preliminary pathogenesis of yellow fat disease in sheep. Eighteen healthy sheep (4–5 months old, 34 ± 1 kg) were selected and randomly divided into three groups: the 10 ppm copper group, the 50 ppm copper group, and the 100 ppm copper group. At the end of the experiment, blood, liver, kidney, and adipose tissue samples were taken from all sheep, and measurements of each index were taken. 50 and 100 ppm copper supplementation in the diets did not significantly affect average daily gain, total cholesterol (TC), triglyceride (TG) and sorbitol dehydrogenase in sheep but significantly increased the effects on gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase enzyme activities in the liver and increased the accumulation of copper in the liver. 50 and 100 ppm copper supplementation to the feed caused different levels of pathological damage to the liver, the kidney, and fat and significantly affected the brightness, redness, and yellowness of the carcass fat. Sheep in the 50 ppm copper group did not show significant clinical symptoms of yellow fat disease in the later period of the experiment, but those in the 100 ppm copper group showed significant clinical symptoms of yellow fat disease. Transcriptome analysis of sheep livers showed differential genes associated with yellow fat disease, and GO and KEGG analyses associated with yellow fat disease were performed, and further correlation analysis found that the occurrence of copper-induced yellow fat disease may be closely related to gene IFIT1.

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