噬菌体在塑造肠道微生物群落中的作用

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-08-21 DOI:10.1080/19490976.2024.2390720
Md Rayhan Mahmud, Sanjida Khanam Tamanna, Sharmin Akter, Lincon Mazumder, Sumona Akter, Md Rakibul Hasan, Mrityunjoy Acharjee, Israt Zahan Esti, Md Saidul Islam, Md Maksudur Rahman Shihab, Md Nahian, Rubaiya Gulshan, Sadia Naser, Anna Maria Pirttilä
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引用次数: 0

摘要

噬菌体是肠道微生物群中最多样化和最主要的成员。它们在塑造肠道微生物群落的结构和功能,进而影响人类和动物的健康方面发挥着至关重要的作用。噬菌体主要存在于粘液中,并能从粘液中转移到肠道器官,起到调节肠道微生物群的作用。了解噬菌体在调节肠道微生物群组成以及影响人类和动物健康方面的重要作用是一个新兴的研究领域。噬菌体在肠道生态系统中的相关性得到了大量证据的支持,但噬菌体在塑造肠道微生物群方面的重要性仍不清楚。虽然有关一般噬菌体生态学和发展的信息已经积累,但有关噬菌体-肠道微生物和噬菌体-人类相互作用的详细知识却缺乏,而且有关噬菌体疗法对人类影响的信息仍不明确。在这篇综述中,我们系统地评估了有关人类和动物肠道环境中噬菌体的结构和生态、它们的发展、可能的相互作用以及随后对肠道生态系统动态的影响的现有数据。我们讨论了噬菌体激活和随后调节肠道细菌的潜在机制。我们还回顾了噬菌体与免疫系统之间的联系,以收集噬菌体影响肠道微生物组成的证据。我们的综述将加深人们对噬菌体在调节肠道微生物群和免疫系统方面的影响的了解,并促进基于噬菌体的疗法的开发,以维持健康和平衡的肠道微生物群。
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Role of bacteriophages in shaping gut microbial community.

Phages are the most diversified and dominant members of the gut virobiota. They play a crucial role in shaping the structure and function of the gut microbial community and consequently the health of humans and animals. Phages are found mainly in the mucus, from where they can translocate to the intestinal organs and act as a modulator of gut microbiota. Understanding the vital role of phages in regulating the composition of intestinal microbiota and influencing human and animal health is an emerging area of research. The relevance of phages in the gut ecosystem is supported by substantial evidence, but the importance of phages in shaping the gut microbiota remains unclear. Although information regarding general phage ecology and development has accumulated, detailed knowledge on phage-gut microbe and phage-human interactions is lacking, and the information on the effects of phage therapy in humans remains ambiguous. In this review, we systematically assess the existing data on the structure and ecology of phages in the human and animal gut environments, their development, possible interaction, and subsequent impact on the gut ecosystem dynamics. We discuss the potential mechanisms of prophage activation and the subsequent modulation of gut bacteria. We also review the link between phages and the immune system to collect evidence on the effect of phages on shaping the gut microbial composition. Our review will improve understanding on the influence of phages in regulating the gut microbiota and the immune system and facilitate the development of phage-based therapies for maintaining a healthy and balanced gut microbiota.

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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
期刊最新文献
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