TTF-1表达对非小细胞肺癌患者免疫疗法和化疗/免疫疗法无进展生存期的影响。

IF 2.7 3区医学 Q3 ONCOLOGY Journal of Cancer Research and Clinical Oncology Pub Date : 2024-08-22 DOI:10.1007/s00432-024-05916-x

Mark Uhlenbruch, Stefan Krüger

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引用次数: 0

摘要

背景：在NSCLC IV期患者中，如何选择使用检查点抑制剂（CPI）的免疫疗法和化疗/免疫疗法（CIT）是经常讨论的问题。有数据表明，化疗效果受 TTF-1 表达的影响。关于甲状腺转录因子1（TTF-1）表达对CIT和CPI治疗的影响，目前所知甚少。我们旨在研究肿瘤TTF-1表达与CIT和CPI疗效之间的关系：我们对 130 名 NSCLC IV 期患者（年龄 68 ± 7 岁）进行了回顾性分析。仅纳入肺腺癌患者。排除了ALK、ROS1、RET、MET、NTRK、表皮生长因子受体（EGFR）、BRAF突变的患者。患者根据指南接受CPI单药（pembrolizumab、nivolumab、atezolizumab、cemiplimab）或CIT（卡铂/培美曲塞/pembrolizumab、卡铂/紫杉醇/atezolizumab）治疗。我们登记了患者的特征，包括 TTF-1 表达。第一组包括40名有CPI和TTF-1表达的患者，第二组包括26名有CPI但无TTF-1表达的患者。第 3 组包括 41 名有 TTF-1 表达的 CIT 患者，第 4 组包括 23 名没有 TTF-1 表达的 CIT 患者：结果：1-4组患者的特征具有可比性。通过 cox 回归分析，我们发现与有 CPI 且无 TTF-1 表达的患者相比，TTF-1 表达可提高无进展生存期（PFS）（18 ± 3.15 个月 vs. 5 ± 0.85 个月，P = 0.004，95% CI：0.23 - 0.984）。在接受CIT治疗的患者中，有TTF-1表达的患者的PFS也有所增加（9 ± 3.17个月 vs. 3 ± 0.399个月，p = 0.001，95% CI：0.23 - 0.85）：在现实生活中，我们发现TTF-1的表达与PFS的增加有关。TTF-1表达的肺腺癌患者接受化疗/免疫治疗和免疫治疗的疗效似乎更好。

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Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer.

Background: The choice between immunotherapy with a checkpoint inhibitor (CPI) and chemo-/immunotherapy (CIT) in patients with NSCLC stage IV is often discussed. There is some data that the effect of chemotherapy is influenced by TTF-1 expression. Little is known about the influence of thyreoid transcription factor 1 (TTF-1) expression on CIT and CPI therapy. We aimed to investigate the relationship between tumor TTF-1 expression and efficacy of CIT and CPI therapy.

Patients and methods: We retrospectively analysed 130 patients (age 68 ± 7 y) with NSCLC stage IV. Only patients with lung adenocarcinoma were included. Patients with ALK, ROS1, RET, MET, NTRK, EGFR, BRAF mutation were excluded. Patients were treated according to the guidelines with either CPI alone (pembrolizumab, nivolumab, atezolizumab, cemiplimab) or CIT (Carboplatin/Pemetrexed/Pembrolizumab, Carboplatin/Paclitaxel/Atezolizumab). We registered patients' characteristics including TTF-1 expression. Group 1 consisted of 40 patients with CPI and TTF-1 expression, group 2 were 26 patients with CPI and with no TTF-1 expression. Group 3 consisted of 41 patients with CIT and TTF-1 expression, group 4 were 23 patients with CIT and with no TTF-1 expression.

Results: Group 1-4 showed comparable patients characteristics. Using cox-regression analysis, we found that TTF-1 expression resulted in an improved progression free survival (PFS) compared to patients with CPI and no TTF-1 expression (18 ± 3,15 vs. 5 ± 0,85 months, p = 0.004, 95% CI: 0,23 - 0,984). In patients, who were treated with CIT, PFS was also increased in patients with TTF-1 expression (9 ± 3,17 vs. 3 ± 0,399 months, p = 0.001, 95% CI: 0,23 - 0,85).

Conclusions: In a real-life setting, we found that TTF-1 expression is associated with an increased PFS. Patients with chemo-/immunotherapy and immunotherapy seem to have a better therapy response in pulmonary adenocarcinoma with TTF-1 expression.

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来源期刊

Journal of Cancer Research and Clinical Oncology 医学-肿瘤学

CiteScore

4.00

自引率

2.80%

发文量

577

审稿时长

2 months

期刊介绍： The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.