酸性槐脂尽管是表面活性剂，但其细胞毒性极小，与个人护理产品中使用的溶剂和油类似。

IF 1.6 4区农林科学 Q3 CHEMISTRY, APPLIED Journal of oleo science Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI:10.5650/jos.ess23259

Wataru Kumano, Michiaki Araki, Akiko Shimada, Yoriko Kato, Yuka Oda, Yoshihiko Hirata

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引用次数: 0

摘要

表面活性剂是一种两亲性物质，可降低表面张力、洗涤和乳化，用途广泛。最近，从可再生资源中提取的具有高生物相容性的生物表面活性剂越来越受到人们的关注。槐脂（Sophorolipid，SL）是一种从星形菌（Starmerella bombicola）中提取的生物表面活性剂，具有去污和乳化特性，因此适用于家庭和个人护理应用。然而，有关 SL 的毒理学数据却很有限。在这项研究中，我们使用 SLs 进行了细胞毒性和皮肤刺激性测试，结果表明 SLs 引发的细胞毒性和皮肤刺激性极低（logIC50 = 4.76 mg/L），与个人护理产品中使用的溶剂和油类相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acid-form Sophorolipids Exhibit Minimal Cytotoxicity, Similar to Solvents and Oils Used in Personal Care Products, despite Being Surfactants.

Surfactants are amphiphilic substances that induce surface tension reduction, washing, and emulsification and are used for various purposes. Recently, biosurfactants manufactured from renewable resources and with high biocompatibility have gained increasing attention. Sophorolipid (SL), a type of biosurfactant derived from Starmerella bombicola, possesses detergency and emulsification properties, making it suitable for household and personal care applications. However, there are limited toxicological data on SLs. In this study, we conducted cytotoxicity and skin-irritation tests using SLs, revealing that cytotoxicity and skin irritation induced by SLs were extremely low (logIC ₅₀ = 4.76 mg/L) and equivalent to those of solvents and oils used in personal care products.

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来源期刊

Journal of oleo science CHEMISTRY, APPLIED-FOOD SCIENCE & TECHNOLOGY

CiteScore

3.20

自引率

6.70%

发文量

173

审稿时长

3 months

期刊介绍： The J. Oleo Sci. publishes original researches of high quality on chemistry, biochemistry and science of fats and oils such as related food products, detergents, natural products, petroleum products, lipids and related proteins and sugars. The Journal also encourages papers on chemistry and/or biochemistry as a major component combined with biological/ sensory/nutritional/toxicological evaluation related to agriculture and/or food.