{"title":"复发性膜性基底细胞腺瘤中 Ki67 表达的改变是否表明需要重新分类?","authors":"Dhinakaran Paranchodi, Ashok Vikey, Jaya Joshi, Ramya Selvam, Neha Choudhary","doi":"10.1016/j.oor.2024.100631","DOIUrl":null,"url":null,"abstract":"<div><p>The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant.</p></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"11 ","pages":"Article 100631"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772906024004771/pdfft?md5=4b84d5ce2885e710f048199ae20a4920&pid=1-s2.0-S2772906024004771-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?\",\"authors\":\"Dhinakaran Paranchodi, Ashok Vikey, Jaya Joshi, Ramya Selvam, Neha Choudhary\",\"doi\":\"10.1016/j.oor.2024.100631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant.</p></div>\",\"PeriodicalId\":94378,\"journal\":{\"name\":\"Oral Oncology Reports\",\"volume\":\"11 \",\"pages\":\"Article 100631\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772906024004771/pdfft?md5=4b84d5ce2885e710f048199ae20a4920&pid=1-s2.0-S2772906024004771-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Oncology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772906024004771\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Oncology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772906024004771","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?
The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant.