复发性膜性基底细胞腺瘤中 Ki67 表达的改变是否表明需要重新分类?

Dhinakaran Paranchodi, Ashok Vikey, Jaya Joshi, Ramya Selvam, Neha Choudhary
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引用次数: 0

摘要

膜性 BCA 复发的发病机制仍不清楚,仅有少数病例报道。本研究的重点是一例表现出高Ki-67增殖指数的病例,这引发了有关Ki-67对预后和治疗方案的影响的问题。我们进行了文献综述,以深入了解膜性 BCA 中 ki67 表达模式的改变。我们还提出了一个假设,认为Ki67水平在5%和10%之间的复发性膜性BCA病例属于中级,需要重新分类。要证实这一假设并了解这种变异的预后,还需要更多的研究。
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Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?

The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant.

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