Cesar A. López , S. Munir Alam , Cynthia A. Derdeyn , Barton F. Haynes , Sandrasegaram Gnanakaran
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引用次数: 0
摘要
最近的一项 I 期疫苗试验显示，呈现 MPER 脂质肽表位的疫苗有望引起广泛的中和反应，这使人们对 HIV 包膜糖蛋白的膜近端外部区域 (MPER) 重新产生了兴趣。MPER 的抗原性与膜密切相关，其表现形式在很大程度上依赖于脂质成分。本综述汇集了有关膜对 MPER 构象的影响及其被广泛中和抗体识别的最新研究成果。具体来说，综述强调了在疫苗设计中适当考虑蛋白质-蛋白质和膜-蛋白质相互作用平衡的重要性。
Influence of membrane on the antigen presentation of the HIV-1 envelope membrane proximal external region (MPER)
The membrane proximal external region (MPER) of the HIV envelope glycoproteins has generated renewed interest after a recent phase I vaccine trial that presented MPER lipid-peptide epitopes demonstrated promise to elicit a broad neutralization response. The antigenicity of MPER is intimately associated with the membrane, and its presentation relies significantly on the lipid composition. This review brings together recent findings on the influence of membranes on the conformation of MPER and its recognition by broadly neutralizing antibodies. Specifically, the review highlights the importance of properly accounting for the balance between protein–protein and membrane–protein interactions in vaccine design.
期刊介绍：
Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In COSB, we help the reader by providing in a systematic manner:
1. The views of experts on current advances in their field in a clear and readable form.
2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
[...]
The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance.
-Folding and Binding-
Nucleic acids and their protein complexes-
Macromolecular Machines-
Theory and Simulation-
Sequences and Topology-
New constructs and expression of proteins-
Membranes-
Engineering and Design-
Carbohydrate-protein interactions and glycosylation-
Biophysical and molecular biological methods-
Multi-protein assemblies in signalling-
Catalysis and Regulation
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