Nidal Jaradat, Mohammad Qneibi, Mohammed Hawash, Mohammad Qadi, Nawaf Al-Maharik, Sosana Bdir, Mohammad Bdair, Jwana Bshir, Nadeen Saleh, Mais Ighbarieh
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引用次数: 0
摘要
背景从植物中提取的精油（EO）成分复杂，为治疗包括神经系统疾病和传染病在内的各种疾病提供了潜在的治疗方法。本研究旨在全面分析海涅鸢尾 EO 的植物化学成分，并评估其药理特性，特别是其细胞毒性、抗菌活性和对 AMPA 受体的调节作用。对几种癌细胞系进行的细胞毒性实验表明，其影响与剂量有关。对表达 AMPARs 的 HEK293T 细胞进行的电生理记录显示，不同亚基受到不同程度的抑制，其中编码 GluA2 的受体表现出最显著的影响。该环氧乙烷还对革兰氏阳性菌、革兰氏阴性菌和真菌具有明显的抗菌活性。结论本研究的结果强调了 I. haynei 环氧乙烷的潜在治疗功效，特别是在治疗与 AMPA 受体功能障碍相关的神经系统疾病和对感染性病原体的抗菌活性方面。这些令人鼓舞的结果值得进一步研究该环氧乙烷的药理作用，为治疗脑缺血和相关神经疾病提供了一种新方法。 图文摘要
Exploring the Iris haynei essential oil: analysis of phytochemical composition, evaluation of cytotoxicity, antimicrobial properties, and AMPA receptor modulation
Background
The complex composition of essential oils (EOs) derived from plants offers potential therapeutic approaches for treating various medical conditions, including neurological disorders and infectious diseases. This research aimed to comprehensively analyze the phytochemical composition of Iris haynei EO and evaluate its pharmacological properties, specifically its cytotoxicity, antimicrobial activity, and modulation of AMPA receptors.
Results
The analysis of I. haynei EO, conducted using gas chromatography and mass spectroscopy, identified diethyl phthalate, α-terpineol, and benzyl acetate as the main components. Cytotoxicity experiments on several cancer cell lines revealed a dose-dependent impact. Electrophysiological recordings on HEK293T cells expressing AMPARs showed varying levels of inhibition across different subunits, with receptors encoding GluA2 exhibiting the most significant effects. The EO also demonstrated significant antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as fungi.
Conclusions
The findings of this study underscore the potential therapeutic benefits of I. haynei EO, particularly in treating neurological conditions associated with AMPA receptor dysfunction and exhibiting antimicrobial activity against infectious agents. The promising results warrant further investigation into the pharmacological effects of the EO, suggesting a novel approach for addressing cerebral ischemia and related neurological diseases.
期刊介绍：
Chemical and Biological Technologies in Agriculture is an international, interdisciplinary, peer-reviewed forum for the advancement and application to all fields of agriculture of modern chemical, biochemical and molecular technologies. The scope of this journal includes chemical and biochemical processes aimed to increase sustainable agricultural and food production, the evaluation of quality and origin of raw primary products and their transformation into foods and chemicals, as well as environmental monitoring and remediation. Of special interest are the effects of chemical and biochemical technologies, also at the nano and supramolecular scale, on the relationships between soil, plants, microorganisms and their environment, with the help of modern bioinformatics. Another special focus is the use of modern bioorganic and biological chemistry to develop new technologies for plant nutrition and bio-stimulation, advancement of biorefineries from biomasses, safe and traceable food products, carbon storage in soil and plants and restoration of contaminated soils to agriculture.
This journal presents the first opportunity to bring together researchers from a wide number of disciplines within the agricultural chemical and biological sciences, from both industry and academia. The principle aim of Chemical and Biological Technologies in Agriculture is to allow the exchange of the most advanced chemical and biochemical knowledge to develop technologies which address one of the most pressing challenges of our times - sustaining a growing world population.
Chemical and Biological Technologies in Agriculture publishes original research articles, short letters and invited reviews. Articles from scientists in industry, academia as well as private research institutes, non-governmental and environmental organizations are encouraged.
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