电池冶炼工人血清铅、铜、铁、锌和血液参数分析:评估铅毒性。

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-08-23 DOI:10.1007/s10534-024-00623-z
Maleeha Sikandar Memon, Ikram Udiin Ujjan, Marvi Shaikh, Sadia Qamar Arain, Arshi Naz, Huma Abbasi
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引用次数: 0

摘要

本研究旨在了解电池冶炼工人血清中的铅、铜、铁和锌水平,以及血液学参数,以评估铅毒性。众所周知,电池冶炼工人暴露于高浓度的铅中,会对健康产生严重的负面影响。对 150 名参与者(包括 75 名电池冶炼工人和 75 名对照组)的血液样本进行了金属浓度和血液指标分析。结果显示,与对照组相比,电池冶炼工人血清中的铅含量明显升高。铅含量的升高还与血红蛋白水平和血细胞比容值的明显下降有关,这表明这些工人可能患有贫血症。此外,还观察到血清中铜、铁和锌水平的变化,这表明铅暴露与这些必需金属的新陈代谢之间可能存在相互作用。这些发现突出表明,有必要定期监测电池冶炼设施和环境,并采取更好的保护措施来预防铅中毒及其相关的血液学紊乱。本研究旨在分析与正常人相比,职业铅暴露对电池工人血液中铅、锌、铁和铜含量的影响,并评估他们的血细胞计数。
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Analysis of serum lead, copper, iron, and zinc and hematological parameters in battery smelting workers: assessing lead toxicity.

The present study is conducted to know the serum lead, copper, iron, and zinc levels, in parallel to hematological parameters, in battery smelting workers to assess lead toxicity. Battery smelting is known to expose workers to high levels of lead, which can have significant negative health effects. Blood samples from 150 participants, including 75 battery smelting workers and 75 controls, were analyzed for metal concentrations and hematological indices. The results revealed significantly elevated levels of lead in the serum of battery smelting workers as compared to control group. Elevated lead levels were also correlated with significantly decreased hemoglobin levels and hematocrit values, manifesting potential anemia in these workers. In addition, disarrangements in serum copper, iron, and zinc levels were also observed, proposing a possible interaction between lead exposure and the metabolism of these essential metals. These findings highlight the need for regular monitoring of battery smelting facilities and environment and to take improved protective measures to prevent lead toxicity and its associated hematological disturbances. This study aims to analyze the effect of occupational lead exposure on blood levels of lead, zinc, iron, and copper in battery workers compared to normal subjects and evaluate their blood counts.

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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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